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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
68
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 3.20nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 4nM
Assay Description:
Inhibition of PARP2 (unknown origin)
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of human PARP2 by trichloroacetic acid precipitation assay
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of PARP2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of PARP2 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.20nM
Assay Description:
Inhibition of human PARP1 by SPA
More data for this Ligand-Target Pair
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3D Structure (crystal)
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.80nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.80nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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MMDB
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antibodypedia
GoogleScholar
Ligand Info
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3D Structure (crystal)
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.80nM
Assay Description:
Inhibition of PARP1 (unknown origin)
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
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GoogleScholar
Ligand Info
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3D Structure (crystal)
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8.10nM
Assay Description:
Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis
More data for this Ligand-Target Pair
Target Info
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Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11.7nM
Assay Description:
Inhibition of PARP1 was assessed using the Universal Chemiluminescent PARPKit. Luminescence readings were normalized to controls and fit to a sigmoid...
More data for this Ligand-Target Pair
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 15nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
More data for this Ligand-Target Pair
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Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 15nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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GoogleScholar
Ligand Info
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CHEMBL
MCE
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Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 16nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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3D Structure (crystal)
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 17nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
MCE
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3D Structure (crystal)
Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 30nM
Assay Description:
Inhibition of GST-tagged recombinant human PARP-1 expressed in Escherichia coli after 30 mins by fluorescence-based assay
More data for this Ligand-Target Pair
Target Info
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MMDB
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UniProtKB/SwissProt
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Ligand Info
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CHEMBL
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 32nM
Assay Description:
Inhibition of recombinant human GST-fused PARP-1 expressed in Escherichia coli after 30 mins by fluorescence assay
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 35nM
Assay Description:
Inhibition of human recombinant N-terminal 6His-6Lys-TEV tagged PARP1 full length expressed in pFastBac expression system incubated for 4 hrs by fluo...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 35nM
Assay Description:
Inhibition of human PARP1 catalytic activity after 10 mins by ELISA
More data for this Ligand-Target Pair
Target Info
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Target
Protein mono-ADP-ribosyltransferase PARP12
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
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Affinity Data
IC50: 79nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
More data for this Ligand-Target Pair
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Target
Protein mono-ADP-ribosyltransferase PARP12
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 79nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
More data for this Ligand-Target Pair
Target Info
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UniProtKB/SwissProt
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 132nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
MCE
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Copy BDB DOI
Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 132nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
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Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 295nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Copy BDB DOI
Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 296nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
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Affinity Data
IC50: 330nM
Assay Description:
Inhibition of human v-PARP catalytic domain by trichloroacetic acid precipitation assay
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 446nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
More data for this Ligand-Target Pair
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 447nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
More data for this Ligand-Target Pair
Target Info
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 570nM
Assay Description:
Inhibition of human TANK1 C-terminal domain by trichloroacetic acid precipitation assay
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Target
Protein mono-ADP-ribosyltransferase PARP3 [R100H]
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Copy SMILES
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Affinity Data
IC50: 1.30E+3nM
Assay Description:
Inhibition of human PARP3 by trichloroacetic acid precipitation assay
More data for this Ligand-Target Pair
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1A
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 1.44E+3nM
Assay Description:
Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...
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Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 1.80E+3nM
Assay Description:
Inhibition of human recombinant N-terminal Avi-6His-TEV tagged PARP2 full length expressed in pFastBac expression system incubated for 4 hrs by fluor...
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Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 1.90E+3nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...
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Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 1.94E+3nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 1B
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 1.95E+3nM
Assay Description:
Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scin...
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Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 1.95E+3nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinyla...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 2.34E+3nM
Assay Description:
Inhibition of recombinant human TNKS1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 2.36E+3nM
Assay Description:
Inhibition of recombinant human TNKS1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 3.31E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP10 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 5.13E+3nM
Assay Description:
Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 5.13E+3nM
Assay Description:
Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...
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Target
Dual specificity tyrosine-phosphorylation-regulated kinase 4
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...
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Dual specificity tyrosine-phosphorylation-regulated kinase 3
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...
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Target
Glycogen synthase kinase-3 beta
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric s...
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Platelet-derived growth factor receptor alpha/beta
(Mus musculus (mouse))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CDK5/p25 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric sc...
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Target
Casein kinase I isoform epsilon
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CK1epsilon expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric ...
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Dual specificity protein kinase CLK1
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...
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Dual specificity tyrosine-phosphorylation-regulated kinase 2
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scint...
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Target
Dual specificity protein kinase CLK4
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...
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Target
Dual specificity protein kinase CLK3
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...
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Target
Dual specificity protein kinase CLK2
(Homo sapiens (Human))
TBA
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: >1.00E+4nM
Assay Description:
Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scinti...
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 1.73E+4nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 1.73E+4nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Protein mono-ADP-ribosyltransferase PARP15
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 2.88E+4nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP15 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Protein mono-ADP-ribosyltransferase PARP15
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: 2.92E+4nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP15 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
IC50: >4.00E+4nM
Assay Description:
Inhibition of human recombinant PARP5a (E1023 to T1327 amino acids) incubated for 4 hrs by fluorescence anisotropy binding assay
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Target
Protein mono-ADP-ribosyltransferase PARP16
(Homo sapiens (Human))
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
Kd: >1.00E+4nM
Assay Description:
Binding affinity to PARP16 (unknown origin) assessed as apparent dissociation constant
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
Kd: >1.00E+4nM
Assay Description:
Binding affinity to PARP14 (unknown origin) assessed as apparent dissociation constant
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Target
Protein mono-ADP-ribosyltransferase PARP12
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
Kd: >1.00E+4nM
Assay Description:
Binding affinity to PARP12 (unknown origin) assessed as apparent dissociation constant
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Target
Protein mono-ADP-ribosyltransferase PARP11
(Homo sapiens)
Astrazeneca
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
Kd: >1.00E+4nM
Assay Description:
Binding affinity to PARP11 (unknown origin) assessed as apparent dissociation constant
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Target
Protein mono-ADP-ribosyltransferase PARP10
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
Kd: 5.00E+3nM
Assay Description:
Binding affinity to PARP10 (unknown origin) assessed as apparent dissociation constant
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
Kd: >1.00E+4nM
Assay Description:
Binding affinity to PARP5b (unknown origin) assessed as apparent dissociation constant
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
Irbm/Merck Research Laboratories
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
Kd: 272nM
Assay Description:
Binding affinity to PARP4 (unknown origin) assessed as apparent dissociation constant
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
Kd: 78nM
Assay Description:
Binding affinity to PARP2 (unknown origin) assessed as apparent dissociation constant
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
Kd: 1nM
Assay Description:
Binding affinity to PARP1 (unknown origin) assessed as apparent dissociation constant
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Affinity Data
EC50: 200nM
Assay Description:
Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay in presence of 100 uM of temozolomide
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
Nirma University
Curated by
ChEMBL
Ligand
BDBM50316226
((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
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Copy InChI
Affinity Data
EC50: 3.10E+4nM
Assay Description:
Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
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PC sid
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In Depth
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Article
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