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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
7
hits in this display
Target
L-lactate dehydrogenase A chain
(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by
ChEMBL
Ligand
BDBM50250675
(CHEMBL4069796 | US10961200, Compound 41 | US112479...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 95nM
Assay Description:
Stabilization of LDHA in human A673 cell lysate preincubated for 20 mins followed by incubation at 70 degreeC for 10 mins by cellular thermal shift a...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
L-lactate dehydrogenase A chain
(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by
ChEMBL
Ligand
BDBM50250675
(CHEMBL4069796 | US10961200, Compound 41 | US112479...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 95nM
Assay Description:
Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and in absence of EDTA by diaphorase/resazurin ba...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
L-lactate dehydrogenase A chain
(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by
ChEMBL
Ligand
BDBM50250675
(CHEMBL4069796 | US10961200, Compound 41 | US112479...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 95nM
Assay Description:
Inhibition of human liver LDHA using sodium pyruvate as substrate after 5 mins in presence of NAPDH and EDTA by diaphorase/resazurin based fluorescen...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
L-lactate dehydrogenase A chain
(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by
ChEMBL
Ligand
BDBM50250675
(CHEMBL4069796 | US10961200, Compound 41 | US112479...)
Copy SMILES
Copy InChI
Affinity Data
IC50: <100nM
Assay Description:
Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
L-lactate dehydrogenase B chain
(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by
ChEMBL
Ligand
BDBM50250675
(CHEMBL4069796 | US10961200, Compound 41 | US112479...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 129nM
Assay Description:
Inhibition of human erythrocytes LDHB using sodium pyruvate as substrate after 5 mins in presence of NAPDH by diaphorase/resazurin based fluorescence...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
L-lactate dehydrogenase A chain
(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by
ChEMBL
Ligand
BDBM50250675
(CHEMBL4069796 | US10961200, Compound 41 | US112479...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >5.70E+4nM
Assay Description:
Inhibition of LDH in human MIAPaCa2 cells assessed as reduction in lactate production preincubated for 2 hrs measured after 30 mins by high throughpu...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Isocitrate dehydrogenase [NADP] cytoplasmic
(Homo sapiens (Human))
National Center For Advancing Translational Sciences
Curated by
ChEMBL
Ligand
BDBM50250675
(CHEMBL4069796 | US10961200, Compound 41 | US112479...)
Copy SMILES
Copy InChI
Affinity Data
IC50: >5.70E+4nM
Assay Description:
Inhibition of wild type IDH1 (unknown origin) using isocitrate as substrate preincubated for 30 mins followed by substrate addition in presence of NA...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI