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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 5 hits in this display   

TargetDNA topoisomerase 1(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259212(CHEMBL2002459 | US10266550, Compound 1)
Affinity DataIC50:  1.95E+3nMAssay Description:The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259212(CHEMBL2002459 | US10266550, Compound 1)
Affinity DataIC50:  3.13E+4nMAssay Description:Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA gyrase subunit B(Escherichia coli (strain K12))
The Florida International University Board of Trustees

US Patent
LigandPNGBDBM50259212(CHEMBL2002459 | US10266550, Compound 1)
Affinity DataIC50: >1.25E+5nMAssay Description:DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259212(CHEMBL2002459 | US10266550, Compound 1)
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
University of Hawaii At Hilo

Curated by ChEMBL
LigandPNGBDBM50259212(CHEMBL2002459 | US10266550, Compound 1)
Affinity DataIC50: >5.00E+5nMAssay Description:Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...More data for this Ligand-Target Pair
In DepthDetails US Patent