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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
11
hits in this display
Target
Calmodulin-domain protein kinase 1
(Toxoplasma gondii)
University of Washington Through Its Center For
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
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Affinity Data
IC50: 86nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
cGMP-dependent protein kinase
()
University of Washington Through Its Center For Commercialization
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 86nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Calmodulin-domain protein kinase 1
(Toxoplasma gondii)
University of Washington Through Its Center For
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 86nM
Assay Description:
Most known kinase inhibitors bind in the ATP-binding pocket of the active site19,20. These inhibitors exploit many of the same hydrophobic contacts a...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 130nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 130nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
More data for this Ligand-Target Pair
Target Info
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Calmodulin-domain protein kinase 1, putative
(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 130nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Calcium/calmodulin dependent protein kinase with a kinas domain and 4 calmodulin-like EF hands
(Cryptosporidium parvum (strain Iowa II))
University of Washington Through Its Center For Commercialization
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 130nM
Assay Description:
Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...
More data for this Ligand-Target Pair
Target Info
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Calcium-dependent protein kinase 1
(Cryptosporidium parvum)
University of Washington Through Its Center For Commercialization
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 130nM
Assay Description:
Two types of enzyme assays were developed to follow TgCDPK1 activity, a radiometric scintillation proximity assay measured the labeled γ-phospha...
More data for this Ligand-Target Pair
Target Info
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Calmodulin-domain protein kinase 1
(Toxoplasma gondii)
University of Washington Through Its Center For
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 990nM
Assay Description:
Inhibition of TgCDPK1 and CpCDPK1 was determined using a luminescent kinase assay which measures ATP depletion in the presence of the Syntide 2 pepti...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
cGMP-dependent protein kinase
()
University of Washington Through Its Center For Commercialization
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 990nM
Assay Description:
Kinase phosphorylation reactions were performed in a buffered medium containing 20 mM HEPES pH 7.5 (KOH), 0.1% BSA, 10 mM MgCl2, 1 mM EGTA (pH 7.2), ...
More data for this Ligand-Target Pair
Target Info
UniProtKB/SwissProt
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI
Target
Calmodulin-domain protein kinase 1
(Toxoplasma gondii)
University of Washington Through Its Center For
US Patent
Ligand
BDBM50345707
(3-(naphthalen-1-ylmethyl)-1-(prop-2-ynyl)-1H-pyraz...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 990nM
Assay Description:
Inhibition of Toxoplasma gondii recombinant N-terminal hexahistidine tagged CDPK1 expressed in Escherichia coli using syntide-2 as substrate after 90...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/TrEMBL
GoogleScholar
Ligand Info
CHEMBL
PC cid
PC sid
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI