Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 8 hits in this display   

TargetProtein-serine O-palmitoleoyltransferase porcupine(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

LigandBDBM50257128(CHEMBL4087906)Copy SMILESCopy InChI

Affinity DataIC50:  12nMAssay Description:Inhibition of porcupine (unknown origin) expressed in HEK293 cells after day 1 post treatment by Super-top flash reporter gene assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathway
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

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TargetStefin-3(Mus musculus)TBA

LigandBDBM50257128(CHEMBL4087906)Copy SMILESCopy InChI

Affinity DataIC50:  12nMAssay Description:Antagonistic activity against histamine H3 receptor in guinea pig ileumMore data for this Ligand-Target Pair

Target InfoKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails PubMed
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TargetCytochrome P450 3A4(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

LigandBDBM50257128(CHEMBL4087906)Copy SMILESCopy InChI

Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetCytochrome P450 2D6(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

LigandBDBM50257128(CHEMBL4087906)Copy SMILESCopy InChI

Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBReactome pathway
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Ligand InfoPC cidPC sid

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TargetCytochrome P450 1A2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

LigandBDBM50257128(CHEMBL4087906)Copy SMILESCopy InChI

Affinity DataIC50:  8.40E+3nMAssay Description:Inhibition of CYP1A2 (unknown origin)More data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

LigandBDBM50257128(CHEMBL4087906)Copy SMILESCopy InChI

Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetDual specificity mitogen-activated protein kinase kinase 5(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

LigandBDBM50257128(CHEMBL4087906)Copy SMILESCopy InChI

Affinity DataKd:  1.30E+3nMAssay Description:Inhibition of partial length human MEK5 expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADantibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
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TargetSerine/threonine-protein kinase RIO2(Homo sapiens (Human))
Experimental Therapeutics Centre

Curated by ChEMBL

LigandBDBM50257128(CHEMBL4087906)Copy SMILESCopy InChI

Affinity DataKd:  7.40E+3nMAssay Description:Inhibition of partial length human RIOK2 expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
antibodypediaGoogleScholar

Ligand InfoPC cidPC sid

In DepthDetails ArticlePubMed
Copy BDB DOI