Home
About
Info
Download
WebServices
Contact
Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
18
hits in this display
Target
Lethal factor
(Bacillus anthracis)
Montana State University
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.40E+3nM ΔG°: -32.3kJ/mole IC50: 2.90E+3nM
pH: 7.2 T: 2°C
Assay Description:
For selected lead compounds from fluorescence-based high-throughput screening, Km and Vmax were calculated using the double-reciprocal Lineweaver-Bur...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA (cytosine-5)-methyltransferase 3-like
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.40E+3nM
Assay Description:
Inhibition of DNMT3A/3L (unknown origin) using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Genome polyprotein
(Dengue virus type 2)
University Of Basel
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.52E+3nM
Assay Description:
Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM site
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Genome polyprotein
(Dengue virus type 2)
University Of Basel
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.16E+3nM
Assay Description:
Inhibition of Dengue virus type 2 NS5 RNA methyltransferase at 8 nM enzyme concentration
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Genome polyprotein
(Dengue virus type 2)
University Of Basel
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.22E+3nM
Assay Description:
Inhibition of Dengue virus type 2 NS5 RNA methyltransferase by spin-down assay
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Genome polyprotein
(Dengue virus type 2)
University Of Basel
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.14E+3nM
Assay Description:
Inhibition of Dengue virus type 2 NS5 RNA methyltransferase at 80 nM enzyme concentration
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
HTH-type transcriptional regulator MgrA
(Staphylococcus aureus)
University Of Nottingham
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8.00E+3nM
Assay Description:
Inhibition of Staphylococcus aureus Newman His6-tagged MgrA expressed in Escherichia coli BL21(DE3) using 5'-6-F-TAAACAACAAGTTGTCCAAA-3' as substrate...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
HTH-type transcriptional regulator MgrA
(Staphylococcus aureus)
University Of Nottingham
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 8.00E+3nM
pH: 7.4 T: 2°C
Assay Description:
A fluorescence anisotropy (FA)-based biochemical assay that monitors MgrA-DNA binding. To determine the binding affinity of MgrA to the labeled DNA,...
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Genome polyprotein
(Dengue virus type 2)
University Of Basel
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9.46E+3nM
Assay Description:
Inhibition of Dengue virus type 2 NS5 RNA methyltransferase SAM site with 0.1 % TX100
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA (cytosine-5)-methyltransferase 3B
(Homo sapiens (Human))
Deutsches Krebsforschungszentrum
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.70E+4nM
Assay Description:
Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA (cytosine-5)-methyltransferase 3-like/3B
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.50E+4nM
Assay Description:
Inhibition of DNMT3B/3L (unknown origin) using poly(2'-deoxyinosinic-2'-deoxycytidylic acid) as substrate after 1 hr by scintillation proximity assay
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.70E+4nM
Assay Description:
Inhibition of DNMT1 (unknown origin) using biotinylated substrate using [3H]-SAM after 1 hr by scintillation proximity assay
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Integrase
(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.18E+4nM
Assay Description:
Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Integrase
(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.78E+4nM
Assay Description:
Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 2
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Integrase
(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 6.04E+4nM
Assay Description:
Inhibitory concentration of compound against strand transfer of HIV-1 integrase in experiment 1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Integrase
(Human immunodeficiency virus 1)
National Cancer Institute-Bethesda
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9.13E+4nM
Assay Description:
Inhibitory concentration of compound against 3'-processing of HIV-1 integrase in experiment 1
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
UniProtKB/TrEMBL
B.MOAD
DrugBank
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human))
Universit£
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9.20E+4nM
Assay Description:
Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Tyrosine-protein phosphatase non-receptor type 1
(Homo sapiens (Human))
Inha University
Curated by
ChEMBL
Ligand
BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.60E+6nM
Assay Description:
Inhibition of PTP1B after 10 mins
More data for this Ligand-Target Pair
Target Info
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
PDB
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI