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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
13
hits in this display
Target
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
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Affinity Data
Ki: 0.230nM
Assay Description:
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
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Target
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 0.340nM
Assay Description:
Displacement of [3H]PGE2 from human prostanoid EP4 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting in presence of 10%...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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PubMed
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Target
Prostaglandin D2 receptor
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
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Affinity Data
Ki: 1.65E+3nM
Assay Description:
Displacement of [3H]PGD2 from human Prostanoid DP1 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
Reactome pathway
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antibodypedia
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Target
Prostaglandin F2-alpha receptor
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
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Affinity Data
Ki: 6.40E+3nM
Assay Description:
Displacement of [3H]PGF2alpha from human prostanoid FP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
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antibodypedia
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Target
Thromboxane A2 receptor
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
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Affinity Data
Ki: 6.70E+3nM
Assay Description:
Displacement of [3H]SQ-29548 from human prostanoid TP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
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antibodypedia
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Target
Prostaglandin E2 receptor EP3 subtype
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 7.40E+3nM
Assay Description:
Displacement of [3H]PGE2 from human prostanoid EP3 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin E2 receptor EP2 subtype
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 8.00E+3nM
Assay Description:
Displacement of [3H]PGE2 from human prostanoid EP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin E2 receptor EP1 subtype
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Copy SMILES
Copy InChI
Affinity Data
Ki: 2.00E+4nM
Assay Description:
Displacement of [3H]PGE2 from human prostanoid EP1 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin D2 receptor 2
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Copy SMILES
Copy InChI
Affinity Data
Ki: >2.10E+4nM
Assay Description:
Displacement of [3H]PGD2 from human Prostanoid DP2 receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
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CHEMBL
PC cid
PC sid
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostacyclin receptor
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
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Affinity Data
Ki: >2.10E+4nM
Assay Description:
Displacement of [3H]iloprost from human prostanoid IP receptor expressed in HEK293-EBNA cells after 60 mins by scintillation counting
More data for this Ligand-Target Pair
Target Info
PDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
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In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.30nM
Assay Description:
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.80nM
Assay Description:
Antagonist activity at human prostanoid EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-induced cAMP accumulation by scintillat...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI
Target
Prostaglandin E2 receptor EP4 subtype
(Homo sapiens (Human))
Merck Frosst Canada
Curated by
ChEMBL
Ligand
BDBM50319837
(4-(1-(1-(4-(trifluoromethyl)benzyl)-1H-indole-7-ca...)
Copy SMILES
Copy InChI
Affinity Data
IC50: 9.5nM
Assay Description:
Antagonist activity at prostanoid EP4 receptor in human whole blood assessed as inhibition of TNFalpha-induced IP-10 release in presence EP4 agonist ...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
Ligand Info
Purchase
CHEMBL
PC cid
PC sid
Patents
Similars
In Depth
Details
Article
PubMed
Copy BDB DOI