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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
5
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Target
DNA topoisomerase 1
(Escherichia coli (strain K12))
The Florida International University Board of Trustees
US Patent
Ligand
BDBM50259213
(CHEMBL4079855 | US10266550, Compound 7e)
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Affinity Data
IC50: 3.13E+4nM
Assay Description:
The relaxation activity of E. coli topoisomerase I was assayed in a buffer containing 10 mM Tris-HCl, pH 8.0, 50 mM NaCl, 0.1 mg/mL gelatin, and 0.5 ...
More data for this Ligand-Target Pair
Target Info
PDB
UniProtKB/SwissProt
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PC sid
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In Depth
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US Patent
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Target
DNA topoisomerase 1
(Homo sapiens (Human))
The Florida International University Board of Trustees
US Patent
Ligand
BDBM50259213
(CHEMBL4079855 | US10266550, Compound 7e)
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Affinity Data
IC50: 3.13E+4nM
Assay Description:
Human topoisomerase I relaxation assays were carried out with 0.5 U of enzyme in reaction buffer supplied by the manufacturer. The enzyme was mixed w...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
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PC sid
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US Patent
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Target
DNA gyrase subunit B
(Escherichia coli (strain K12))
The Florida International University Board of Trustees
US Patent
Ligand
BDBM50259213
(CHEMBL4079855 | US10266550, Compound 7e)
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Affinity Data
IC50: 6.25E+4nM
Assay Description:
DNA gyrase supercoiling assays were carried out by mixing the compounds and the enzyme in a similar manner as above (EcTopI relaxation inhibition ass...
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Target Info
PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
Ligand Info
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PC sid
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In Depth
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US Patent
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Target
DNA topoisomerase 2-alpha
(Homo sapiens (Human))
University of Hawaii At Hilo
Curated by
ChEMBL
Ligand
BDBM50259213
(CHEMBL4079855 | US10266550, Compound 7e)
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Affinity Data
IC50: 1.25E+5nM
Assay Description:
Inhibition of human topoisomerase-2alpha assessed as reduction in enzyme-mediated decatenation using kinetoplast DNA as substrate after 15 mins by et...
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Target Info
PDB
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antibodypedia
GoogleScholar
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Article
PubMed
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Target
DNA topoisomerase 2-alpha
(Homo sapiens (Human))
University of Hawaii At Hilo
Curated by
ChEMBL
Ligand
BDBM50259213
(CHEMBL4079855 | US10266550, Compound 7e)
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Affinity Data
IC50: 1.25E+5nM
Assay Description:
Human Topoisomerase IIα assays were carried out by adding the compounds to 185 ng of kinetoplast DNA (kDNA, from TopoGen) in the buffer supplied...
More data for this Ligand-Target Pair
Target Info
PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
Ligand Info
PC cid
PC sid
Similars
In Depth
Details
US Patent
Copy BDB DOI