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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 12 hits in this display   

TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataKi:  8.50E+3nMAssay Description:Competitive type inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataKi:  3.45E+4nMAssay Description:Competitive type inhibition of diphenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA substrate by UV...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicansMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPyruvate kinase PKM(Homo sapiens (Human))
Universit£ di Pisa

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibition of recombinant PKM2 (unknown origin) Asp178, Asp177, Hie78, Lys367, Asn75, Il61, Ser362, Gly128 residuesMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Sejong University

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataIC50:  1.57E+4nMAssay Description:Inhibition of N-terminal GST-His-tagged c-KIT (544 to 976 amino acids) D816V mutant (unknown origin) expressed in Sf9 insect cells using poly[Glu:Tyr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Sejong University

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibition of wild type His-tagged c-KIT (544 to 976 amino acids) (unknown origin) expressed in insect cells using poly[Glu:Tyr] (4:1) as substrate p...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of monophenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-Tyrosine substrate by UV-Vis spectr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Gyeongsang National University

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinase assessed as reduction in dopachrome formation using L-DOPA substrate by UV-Vis spectrophoto...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibition of human Beta-secretase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Kyoto University

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of wild type Amyloid beta (1 to 42) (unknown origin) aggregation by Thioflavin-T fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Kyungpook National University

Curated by ChEMBL
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataIC50:  3.50E+4nMAssay Description:Inhibition of human Beta-secretase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50084980((+)-taxifolin | (-)-Epicatechol | (2R,3R)-(-)-Epic...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibitory activity against protein kinase C (PKC)More data for this Ligand-Target Pair
In DepthDetails Article