Compile Data Set for Download or QSAR
maximum 50k data

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 24 hits in this display   

TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nankai University

LigandPNGBDBM108215(5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyrid...)
Affinity DataKi:  33.1nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  400nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3965 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3130 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-mannosidase(Bacteroides thetaiotaomicron)
The Medical School, Newcastle University

LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  1.40E+3nM ΔG°:  -34.8kJ/molepH: 5.6 T: 2°CAssay Description:Putative mannosidase assay using wild-type protein Btman2A. Enzyme inhibition assay.More data for this Ligand-Target Pair
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  4.30E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3994 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  4.60E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3991 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  7.00E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 2948 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  9.00E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 2199 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  9.60E+4nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3990 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  2.60E+5nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3858 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  2.70E+5nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3962 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  3.60E+5nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 4073 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  6.00E+5nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 1032 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  7.90E+5nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3963 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  8.60E+5nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 4093 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  1.60E+6nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 4092 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  1.80E+6nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 1878 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1,2-mannosidase, putative(Bacteroides thetaiotaomicron )
Newcastle University

Curated by ChEMBL
LigandPNGBDBM36373((5R,6R,7S,8R)-5,6,7,8-Tetrahydro-5-(hydroxymethyl)...)
Affinity DataKi:  5.80E+6nMAssay Description:Inhibition of Bacteroides thetaiotaomicron GH92 alpha-mannosidase 3784 assessed as reduction of mannose release using 4NP-mannopyranoside substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nankai University

LigandPNGBDBM108215(5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyrid...)
Affinity DataIC50:  79.2nMpH: 7.0Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Nankai University

LigandPNGBDBM108215(5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyrid...)
Affinity DataIC50:  91.6nMpH: 5.2Assay Description:The assays were performed at 37°C with 4-MU-β-ᴅ-Glu as the substrate in Mcllvaine buffer (sodium citrate (100mM) and sodium phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPrunasin hydrolase(Prunus dulcis (Almond))
Nankai University

LigandPNGBDBM108215(5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyrid...)
Affinity DataIC50:  220nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-galactosidase(Bos taurus (Bovine))
Nankai University

LigandPNGBDBM108215(5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyrid...)
Affinity DataIC50:  230nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-galactosidase(Coffea arabica (Coffee beans))
Nankai University

LigandPNGBDBM108215(5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyrid...)
Affinity DataIC50:  7.29E+3nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOligo-1,6-glucosidase IMA1(Saccharomyces cerevisiae S288c (Baker's yeast))
Nankai University

LigandPNGBDBM108215(5-(hydroxymethyl)-5H,6H,7H,8H-imidazo[1,2- a]pyrid...)
Affinity DataIC50:  9.85E+4nMpH: 10.6 T: 2°CAssay Description:In a 96-well plates, 10µL of commercial enzyme solutions without (control) or with 20µL of inhibitor were incubated at 37°C for 5 min....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed