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Compile Data Set for Download or QSAR
maximum 50k data
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
(change energy unit to
kcal/mol
)
Found
50
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
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Affinity Data
Ki: 100nM
Assay Description:
Antagonistic activity against histamine H3 receptor in guinea pig ileum
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
Ki: 100nM
Assay Description:
Antagonistic activity against histamine H3 receptor in guinea pig ileum
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 1.90nM
Assay Description:
Inhibition of TNKS1 (unknown origin) using biotin-NAD+ as substrate incubated for 1 hr in the presence of deoxy-oligonucleotide by ELISA analysis rel...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of human N-terminal GST-tagged TNKS2 (667 to 1166 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate ...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.10nM
Assay Description:
Inhibition of TNKS2 (unknown origin) using biotin-NAD+ as substrate incubated for 1 hr in the presence of deoxy-oligonucleotide by ELISA analysis rel...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 2.20nM
Assay Description:
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.30nM
Assay Description:
Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS2 SAM-PARP domain (613 to 1166 residues) expressed in Esc...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 3.60nM
Assay Description:
Inhibition of GST-tagged human recombinant TNKS2 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assay
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4nM
Assay Description:
Antagonistic activity against histamine H3 receptor in guinea pig ileum
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4nM
Assay Description:
Inhibition of TNKS2 (unknown origin)
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 4.20nM
Assay Description:
Inhibition of human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected Sf9 insect cells using histone as substrate...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.20nM
Assay Description:
Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.25nM
Assay Description:
Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 7.5nM
Assay Description:
Inhibition of recombinant human N-terminal TEV cleavage site-fused/FLAG-poly his-tagged TNKS SAM-PARP domain (1024 to 1327 residues) expressed in Esc...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 10nM
Assay Description:
Inhibition of TNKS-1 (unknown origin) using histone as substrate incubated for 30 mins by colorimetric assay
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Inhibition of TNKS1 (unknown origin)
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Antagonistic activity against histamine H3 receptor in guinea pig ileum
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Target
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human))
Universitaire Vaudois
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Inhibition of tankyrase1/2 (unknown origin)
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 11nM
Assay Description:
Inhibition of GST-tagged human recombinant TNKS1 incubated for 1 hr using NAD+, biotinylated NAD+ and activated DNA by luminescence based assay
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 13nM
Assay Description:
Inhibition of TNKS1 (unknown origin) by biochemical assay
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 17nM
Assay Description:
Inhibition of N-terminal GST-tagged human TNKS-2 (849 to 1166 residues) expressed in in insect sf21 cells preincubated for 2 hrs followed by substrat...
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 27nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 74nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 95nM
Assay Description:
Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...
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Target
Poly [ADP-ribose] polymerase tankyrase-1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 95.5nM
Assay Description:
Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 m...
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
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Affinity Data
IC50: 114nM
Assay Description:
Inhibition of PAPR2 (unknown origin)
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 114nM
Assay Description:
Effect on IP3 turnover by phospholipaseC positively linked to human NK1 receptor expressed in CHO cells
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 114nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP2 autophosphorylation at ADP-ribosyltransferase domain by LC-MS/MS method
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 120nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP1
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 166nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 169nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
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Target
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human))
Universitaire Vaudois
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 351nM
Assay Description:
Inhibition of TNKS/TNKS2 (unknown origin) expressed in human DLD1 cells assessed as reduction in Wnt-signaling measured after 24 hrs by TCF-luciferas...
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Target
Poly [ADP-ribose] polymerase tankyrase-1/tankyrase-2
(Homo sapiens (Human))
Universitaire Vaudois
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 707nM
Assay Description:
Inhibition of tankyrase in human DLD1 cells assessed as reduction in Wnt activity after 24 hrs by TCF-luciferase reporter gene assay
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Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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IC50: 832nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
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Target
Protein mono-ADP-ribosyltransferase PARP3
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: 839nM
Assay Description:
Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylat...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: 1.20E+3nM
Assay Description:
Inhibition of PARP-1 (unknown origin) using histone as substrate incubated for 1 hr by chemiluminescence assay
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: 2.19E+3nM
Assay Description:
Inhibition of PARP1 (unknown origin)
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: 2.20E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP1 autophosphorylation at ADP-ribosyltransferase domain by LC-MS/MS method
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: 4.37E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: 4.39E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins foll...
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Target
Protein mono-ADP-ribosyltransferase PARP4
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: <5.01E+3nM
Assay Description:
Binding affinity to PARP4 in human Jurkat cell extract after 45 mins by mass spectrometric analysis
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: <5.01E+3nM
Assay Description:
Binding affinity to PARP14 in human Jurkat cell extract after 45 mins by mass spectrometric analysis
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Target
Poly [ADP-ribose] polymerase 2
(Homo sapiens (Human))
Health & Science University
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: <5.01E+3nM
Assay Description:
Binding affinity to PARP2 in human Jurkat cell extract after 45 mins by mass spectrometric analysis
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Protein mono-ADP-ribosyltransferase PARP11
(Homo sapiens)
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: <5.01E+3nM
Assay Description:
Binding affinity to PARP11 in human Jurkat cell extract after 45 mins by mass spectrometric analysis
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Protein mono-ADP-ribosyltransferase PARP16
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: <5.01E+3nM
Assay Description:
Binding affinity to PARP16 in human Jurkat cell extract after 45 mins by mass spectrometric analysis
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: 5.89E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Protein mono-ADP-ribosyltransferase PARP14
(Homo sapiens (Human))
Glaxosmithkline
Curated by
ChEMBL
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
Copy SMILES
Copy InChI
Affinity Data
IC50: 5.90E+3nM
Assay Description:
Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins fol...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
IC50: 3.49E+4nM
Assay Description:
Inhibition of recombinant human PARP1 expressed in Escherichia coli assessed as reduction in auto-PARylation using histone as substrate measured afte...
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Target
Poly [ADP-ribose] polymerase tankyrase-2
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Kd: 4.20nM
Assay Description:
Binding affinity to recombinant human N-terminal His-tagged TNKS2 (Ser959 to Gly1166 residues) expressed in Escherichia coli by surface plasmon reson...
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Target
Poly [ADP-ribose] polymerase 1
(Homo sapiens (Human))
TBA
Ligand
BDBM50188594
(CHEBI:62878 | CHEMBL1086580)
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Affinity Data
Kd: 1.20E+3nM
Assay Description:
Antagonistic activity against histamine H3 receptor in guinea pig ileum
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