Compile Data Set for Download or QSAR
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB (change energy unit to kcal/mol)

Found 33 hits in this display   

TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  4.00E+3nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  4.00E+3nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  4.00E+3nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  9.00E+3nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  9.00E+3nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  9.00E+3nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  1.00E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  2.25E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  2.25E+4nMAssay Description:Table 1 shows the IC50 of curcumin, compound 1, and compound 2, compared to a standard Zn++ binding & MMPI (matrix metalloproteinase inhibitor), 1,10...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetRecBCD enzyme subunit RecD(Escherichia coli str. K-12 substr. MG1655)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  3.05E+4nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Affiliation: The Scripps Research Institute, TSRI Assa...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetNeutrophil collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  3.50E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGalanin receptor type 2(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50: >4.20E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Research Institute (TSRI) Assay Provid...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetGalanin receptor type 2(Homo sapiens (Human))
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50: >4.20E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: The Scripps Florida Research Institute, TSRI Assay...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  5.01E+4nMAssay Description:Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  5.30E+4nMAssay Description:Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVIM-13(Pseudomonas aeruginosa)
Hospital Son Dureta

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  6.93E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa VIM-13 beta-lactamase after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  7.00E+4nMT: 2°CAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  7.00E+4nMAssay Description:Table 10: The efficacy of MMP-2 inhibition was as follows: compound 6>compound 7>compound 8. Although compound 6 showed similar efficacy as curcumin ...More data for this Ligand-Target Pair
In DepthDetails US Patent
Target72 kDa type IV collagenase(Homo sapiens (Human))
The Research Foundation of State University of New York

US Patent
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  7.00E+4nMAssay Description:It has been observed that 50 and 100 μM concentrations of curcumin decreased TNFα production by endotoxin-stimulated human monocytes (HMs) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVIM-1 protein(Pseudomonas aeruginosa)
Hospital Son Dureta

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  7.30E+4nMAssay Description:Inhibition of Pseudomonas aeruginosa VIM-1 beta-lactamase after 10 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  7.40E+4nMAssay Description:Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  7.94E+4nMAssay Description:Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase ColG(Clostridium histolyticum)
Osaka Organic Chemical Industry

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  1.85E+5nMAssay Description:Inhibition of Clostridium histolyticum collagenase after 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThermolysin(Bacillus thermoproteolyticus)
Osaka Organic Chemical Industry

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  3.60E+5nMAssay Description:Inhibition of Bacillus thermoproteolyticus thermolysin after 15 minMore data for this Ligand-Target Pair
TargetCarboxypeptidase A1(Bos taurus (bovine))
Osaka Organic Chemical Industry

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  4.22E+5nMAssay Description:Inhibition of Bos taurus (bovine) pancrease carboxypeptidase A after 15 minMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSnake venom metalloproteinase neuwiedase(Bothrops pauloensis)
Instituto De Ci£Ncias Exatas

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  4.70E+5nMAssay Description:Inhibition of Bothrops pauloensis MP1 assessed as reduction in azocaseinolytic activity after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataIC50:  4.00E+6nMAssay Description:Inhibition of [3H]-farnesyl pyrophosphate binding to human farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataEC50:  5.01E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataEC50:  6.31E+3nMAssay Description:Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataEC50:  5.90E+3nMAssay Description:Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataEC50:  3.98E+3nMAssay Description:Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataEC50:  4.90E+3nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50092158(1,10-phenanthroline | CHEMBL415879 | US10669227, C...)
Affinity DataEC50:  3.90E+3nMAssay Description:Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed