Found 51 Enz. Inhib. hit(s) with all data for entry = 50012347 TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-i...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS bindin...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 7.20nMAssay Description:Antagonist activity at human Flag-tagged Gialpha-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induc...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Antagonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS binding pr...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 55nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Affinity DataIC50: 68nMAssay Description:Antagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in PSB-16671-induced stim...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 83nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
Affinity DataIC50: 126nMAssay Description:Antagonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as reduction in ZQ-16-induced stimulat...More data for this Ligand-Target Pair
Affinity DataIC50: 145nMAssay Description:Antagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in PSB-16671-induced stimulation of [35S]GTPgammaS bi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 168nMAssay Description:Antagonist activity at recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cells assessed as inhibi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 260nMAssay Description:Antagonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in 6-OAU-induced inhibition of forskolin stimulated cAMP productio...More data for this Ligand-Target Pair
Affinity DataIC50: 316nMAssay Description:Antagonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as reduction in ZQ-16-induced stimulation of [35S]GTPgammaS bindin...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 1.70E+4nMAssay Description:Antagonist activity at human C-terminal GFP10-fused GPR84 expressed in HEK293 cells co-expressing Rluc8-tagged Galphai2/GFP10-tagged Ggamma2/Gbeta1 a...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 2.08E+5nMAssay Description:Antagonist activity at human C-terminal GFP10-fused GPR84 expressed in HEK293 cells co-expressing Rluc8-tagged Galphai2/GFP10-tagged Ggamma2/Gbeta1 a...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.98E+5nMAssay Description:Antagonist activity at human C-terminal GFP10-fused GPR84 expressed in HEK293 cells co-expressing Rluc8-tagged Galphai2/GFP10-tagged Ggamma2/Gbeta1 a...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 115nMAssay Description:Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid ...More data for this Ligand-Target Pair
Affinity DataEC50: 26nMAssay Description:Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liq...More data for this Ligand-Target Pair
Affinity DataEC50: 178nMAssay Description:Agonist activity at GPR84 in LPS-treated mouse RAW 264.7 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liq...More data for this Ligand-Target Pair
Affinity DataEC50: 13nMAssay Description:Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.88E+3nMAssay Description:Agonist activity at GPR84 in mouse bone-marrow-derived neutrophils assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid ...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 1.60nMAssay Description:Agonist activity at human GPR84 expressed in HEK293 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 60 mins by HTRF...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataKd: 0.240nMAssay Description:Binding affinity to recombinant human N-terminal epitope tagged/eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membrane incubated for...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 5.00E+3nMAssay Description:Agonist activity at human GPR84 expressed in CHO cells assessed as induction of beta-arrestin recruitment by chemiluminescence PathHunter assayMore data for this Ligand-Target Pair
3D Structure (crystal)TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 16nMAssay Description:Agonist activity at GPR84 in LPS-treated human THP-1 cell membrane assessed as stimulation of [35S]GTPgammaS binding incubated for 60 mins by liquid ...More data for this Ligand-Target Pair
Affinity DataEC50: 295nMAssay Description:Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding ...More data for this Ligand-Target Pair
Affinity DataEC50: 4.27E+3nMAssay Description:Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding ...More data for this Ligand-Target Pair
Affinity DataEC50: 30nMAssay Description:Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding ...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 525nMAssay Description:Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding ...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 29nMAssay Description:Agonist activity at human Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding ...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: >6.00E+4nMAssay Description:Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: >2.00E+4nMAssay Description:Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 501nMAssay Description:Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 8.13E+3nMAssay Description:Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 1.10E+4nMAssay Description:Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as induction of beta-arrestin recruitment by luminescence assayMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 33nMAssay Description:Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by lumi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 12nMAssay Description:Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by lumi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 19nMAssay Description:Agonist activity at human GPR84 expressed in CHO-K1 cells assessed as reduction in forskolin-stimulated cAMP production incubated for 30 mins by lumi...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 1.30E+4nMAssay Description:Agonist activity at human Gialpha-coupled GPR84 expressed in baculovirus infected sf9 insect cells assessed as induction of [35S]GTPgammaS incubated ...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 1.44E+4nMAssay Description:Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid sc...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 1.05E+4nMAssay Description:Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid sc...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 8.60E+3nMAssay Description:Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid sc...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 7.02E+4nMAssay Description:Agonist activity at human GPR84 expressed in CHO cell membranes assessed as induction of [35S]GTPgammaS incorporation incubated for 1 hr by liquid sc...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 8.80E+3nMAssay Description:Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followe...More data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Chinese Academy Of Sciences
Curated by ChEMBL
Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataEC50: 5.23E+4nMAssay Description:Agonist activity at human GPR84 expressed in CHO cells assessed as reduction in forskolin-stimulated cAMP production preincubated for 20 mins followe...More data for this Ligand-Target Pair
