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Found 4 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50214924'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214924((Z)-5-(4-(trifluoromethoxy)benzylidene)-10-methoxy...)
Affinity DataKi:  4.30nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214924((Z)-5-(4-(trifluoromethoxy)benzylidene)-10-methoxy...)
Affinity DataIC50:  91nMAssay Description:Activity at GR assessed as repression of TNFalpha and IL 1beta induced E-selectin responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214924((Z)-5-(4-(trifluoromethoxy)benzylidene)-10-methoxy...)
Affinity DataEC50:  437nMAssay Description:Agonist activity at GR by GRE activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214924((Z)-5-(4-(trifluoromethoxy)benzylidene)-10-methoxy...)
Affinity DataEC50: >1.00E+3nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed