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Found 5 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50214925'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214925(5-[1-biphenyl-3-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataKi:  7.20nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214925(5-[1-biphenyl-3-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214925(5-[1-biphenyl-3-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataIC50:  12nMAssay Description:Activity at GR assessed as repression of TNFalpha and IL 1beta induced E-selectin responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214925(5-[1-biphenyl-3-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at GR by GRE activation assay relative to dexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214925(5-[1-biphenyl-3-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at GR by GRE activation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed