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Found 3 Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50274929'
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50274929((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2,6-difl...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from human GnRH receptor expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Rattus norvegicus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50274929((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2,6-difl...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I-Tyr5,DLeu6,NMeLeu7,Pro9-NEt-]GnRH from rat GnRH receptor expressed in CHO cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGonadotropin-releasing hormone receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50274929((R)-4-{2-[5-(2-Fluoro-3-methoxyphenyl)-3-(2,6-difl...)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at human GnRH receptor expressed in RBL1 cells assessed as inhibition of GnRH-stimulated inositol phosphate productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed