Found 8 Enz. Inhib. hit(s) with Target = 'NAD-dependent protein deacetylase sirtuin-2' and Ligand = 'BDBM50276140' TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of human N-terminal His6-SUMO-tagged SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 using H3K9AcWW as substrate preincubate...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of recombinant human N-terminal His6-tagged/SUMO-fused SIRT2 (38 to 356 residues) expressed in Escherichia coli BL21 assessed as reduction...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 93nMAssay Description:Inhibition of human SIRT2 deacetylation activity using H3K9Ac as substrate preincubated for 15 mins in presence of NAD+ by HPLC analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human SIRT2 deacylation activity using Fluor de Lys Sirt2 as substrate measured at 5 mins interval for 30 mins in presence ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of human SIRT2 deacetylation activity using H3K9Ac as substrate in presence of NAD+ by HPLC analysisMore data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 370nMAssay Description:Inhibition of human SIRT2 defatty-acylation activity using peptide substrate preincubated in presence of NAD+ followed by substrate addition by HPLC ...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of recombinant human SIRT2 defatty-acylase activity using SFP3 as substrate measured at 5 mins interval for 60 mins in presence of NAD+ by...More data for this Ligand-Target Pair
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
School of Pharmacy
Curated by ChEMBL
School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: >8.30E+4nMAssay Description:Inhibition of human SIRT2 defatty-acylation activity using peptide substrate in presence of NAD+ by HPLC analysisMore data for this Ligand-Target Pair
