Found 3 Enz. Inhib. hit(s) with Target = 'Presenilin-1' and Ligand = 'BDBM50477715' TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of gamma-secretase assessed as reduction of amyloid-beta 42 levelsMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 2.80nMAssay Description:Inhibition of gamma-secretase assessed as reduction of amyloid-beta 40 levels in H4 cellsMore data for this Ligand-Target Pair
TargetPresenilin-1(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Bristol-Myers Squibb Research and Development
Curated by ChEMBL
Affinity DataIC50: 4.10nMAssay Description:Inhibition of gamma-secretase in human H4 cells expressing APP751 Swedish mutant assessed as inhibition of amyloid beta40 production after 19 hrsMore data for this Ligand-Target Pair
