Found 35 Enz. Inhib. hit(s) with Target = 'Receptor-type tyrosine-protein kinase FLT3' and Ligand = 'BDBM2579'
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human N-terminal GST-tagged FLT3 (564 to 993 residues) expressed in baculovirus expression system using peptide FAM-P2 as substrate inc...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of FLT3 (unknown origin) incubated for 1 hr by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 0.254nMAssay Description:Inhibition of recombinant His-tagged human FLT3 D835Y mutant (564 to 958 residues) expressed in baculovirus expression system by LanthaScreen assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 0.259nMAssay Description:Inhibition of recombinant N-terminal GST/His6-tagged human FLT3 ITD mutant (571 to 993 residues) expressed in insect cells by LanthaScreen assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 0.520nMAssay Description:Inhibition of FLT3 (unknown origin) by HTRF methodMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 0.710nMAssay Description:Inhibition of human FLT3 D835Y mutant by Hotspot assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 0.755nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 0.830nMAssay Description:Inhibition of human FLT3 R595_E596 mutant by Hotspot assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of FLT3 (unknown origin) after 40 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of FLT3 (unknown origin) using EAIYAAPFAKKK substrateMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human FLT3 by Hotspot assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human FLT3 F594_R595insR mutant by Hotspot assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human FLT3 ITD-W51 mutant by Hotspot assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human FLT3 F594_R595insREY mutant by Hotspot assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of FLT3 (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human FLT3 Y591-V592 mutant by Hotspot assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inhibition of human FLT3 ITD-NPOS mutant by Hotspot assayMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 2.90nMAssay Description:Binding constant for FLT3 kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 2.5nMAssay Description:Binding constant for FLT3(D835Y) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 2.40nMAssay Description:Binding constant for FLT3(ITD) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 1.80nMAssay Description:Average Binding Constant for FLT3; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 3.30nMAssay Description:Binding constant for FLT3(K663Q) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 2.5nMAssay Description:Binding constant for FLT3(D835Y) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 2.10nMAssay Description:Binding constant for FLT3(D835H) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 2.40nMAssay Description:Binding constant for FLT3(ITD) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 2.10nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 0.220nMAssay Description:Binding constant for FLT3(R834Q) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 2.90nMAssay Description:Binding constant for FLT3 kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 2.10nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
East China University of Science & Technology
Curated by ChEMBL
East China University of Science & Technology
Curated by ChEMBL
Affinity DataKd: 2.10nMAssay Description:Binding constant for FLT3(D835H) kinase domainMore data for this Ligand-Target Pair