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Found 7 Enz. Inhib. hit(s) with Target = 'Squalene synthase' and Ligand = 'BDBM50213690'
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50213690(2-Biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazi...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as decrease in conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50213690(2-Biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazi...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of squalene synthase in rat liver microsome measured by convertion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50213690(2-Biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazi...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as [3H] FPP to squalene conversion level after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50213690(2-Biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazi...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of SQS in rat liver microsomes assessed as reduction in [3H]FPP conversion to squalene preincubated for 10 mins followed by [3H]FPP additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50213690(2-Biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazi...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of squalene synthase in rat liver microsomes assessed as inhibition of [3H] FPP conversion to squalene after 10 mins by scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50213690(2-Biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazi...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of SQS in rat microsomes using [3H]-FPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by sci...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSqualene synthase(Rattus norvegicus)
University Of Athens

Curated by ChEMBL
LigandPNGBDBM50213690(2-Biphenyl-4-yl-4-methyl-octahydro-benzo[1,4]oxazi...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of rat microsomal squalene synthase activity assessed as conversion of [3H]FPP to squaleneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed