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Found 4 Enz. Inhib. hit(s) with Target = 'TGF-beta receptor type-1' and Ligand = 'BDBM50056676'
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50056676(CHEMBL3341789)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50056676(CHEMBL3341789)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50056676(CHEMBL3341789)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of ALK5 (unknown origin) transfected in human HEK293T cells cotransfected with CAGA reporter encoding luciferase by luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
University of Toronto

Curated by ChEMBL
LigandPNGBDBM50056676(CHEMBL3341789)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed