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Found 1027 of ic50 for UniProtKB: P05622
LigandPNGBDBM50408387(CHEMBL5268482)
Affinity DataIC50:  0.0400nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
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LigandPNGBDBM50477652(CHEMBL250790)
Affinity DataIC50:  0.0900nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50608338(CHEMBL5268427)
Affinity DataIC50:  0.140nMAssay Description:Inhibition of Staphylococcus aureus DNA gyraseMore data for this Ligand-Target Pair
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LigandPNGBDBM50518950(CHEMBL4468881)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50608648(CHEMBL5286715)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
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LigandPNGBDBM50608647(CHEMBL5267724)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
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LigandPNGBDBM50608649(CHEMBL5290499)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
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LigandPNGBDBM50608650(CHEMBL5271348)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
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LigandPNGBDBM50608646(CHEMBL5288936)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
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LigandPNGBDBM50450068(CHEMBL5275288)
Affinity DataIC50:  0.216nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) incubated for 60 mins in presence of ATP by ADP-Glo luminescent Kinase AssayMore data for this Ligand-Target Pair
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LigandPNGBDBM50450067(CHEMBL5279750)
Affinity DataIC50:  0.216nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) incubated for 60 mins in presence of ATP by ADP-Glo luminescent Kinase AssayMore data for this Ligand-Target Pair
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LigandPNGBDBM50408386(CHEMBL5287343)
Affinity DataIC50:  0.260nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
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LigandPNGBDBM50411638(CHEMBL404371)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
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LigandPNGBDBM50226181((3R,4S,5R,6R)-5-hydroxy-6-(4-hydroxy-3-(4-hydroxy-...)
Affinity DataIC50:  0.650nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling incubated for 30 mins in presence of ATP by ethidium bromide staining based analysisMore data for this Ligand-Target Pair
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LigandPNGBDBM50407412(CHEMBL5269793)
Affinity DataIC50:  0.700nMAssay Description:Activity at Histamine H2 receptor using functional H2 receptor assay on guinea pig atriumMore data for this Ligand-Target Pair
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LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  0.770nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
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LigandPNGBDBM50000334(6,7-Dichloro-1,5-dihydro-imidazo[2,1-b]quinazolin-...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of PDE3 (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50608668(CHEMBL5282942)
Affinity DataIC50:  0.950nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as relaxation of pBR322 DNA by supercoiling assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50613596(CHEMBL5272356)
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  1nMAssay Description:Inhibition of GST-tagged human CDK2/Cyclin A2 expressed in baculovirus infected Sf9 cells using 5-FAM-QSPKKG-CONH2 as substrate incubated for 60 mins...More data for this Ligand-Target Pair
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LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50:  1nMAssay Description:Ability to displace [3H]glycine from strychnine-insensitive glycine receptorMore data for this Ligand-Target Pair
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LigandPNGBDBM50613594(CHEMBL5275755)
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50613593(CHEMBL5285324)
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50613595(CHEMBL5272100)
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50613597(CHEMBL5270626)
Affinity DataIC50: <1nMAssay Description:Inhibition of JAK (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50613099(CHEMBL5288212)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase supercoiling incubated for 30 mins in presence of ATP by ethidium bromide staining based analysisMore data for this Ligand-Target Pair
Ligand InfoPDB
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LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BCR-ABL (unknown origin) expressed in mouse BaF3 cells assessed as cell growth inhibition incubated for 20 mins by TR-FRET assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50239948(CHEMBL4071326 | US9850225, Example 1166)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human PD-1/PD-L1 interactionMore data for this Ligand-Target Pair
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LigandPNGBDBM50610586(CHEMBL5280445)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM50450065(CHEMBL5286795)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) incubated for 60 mins in presence of ATP by ADP-Glo luminescent Kinase AssayMore data for this Ligand-Target Pair
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LigandPNGBDBM50614520(CHEMBL5271228)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of CDK2/Cyclin E1 (unknown origin) assessed as inhibition of substrate peptide phosphorylation using eIF4E-binding protein 1 as peptide su...More data for this Ligand-Target Pair
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LigandPNGBDBM50608645(CHEMBL4535844)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
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LigandPNGBDBM50608666(CHEMBL5267457)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as relaxation of pBR322 DNA by supercoiling assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50450066(CHEMBL5283958)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of CDK2/cyclin E1 (unknown origin) incubated for 60 mins in presence of ATP by ADP-Glo luminescent Kinase AssayMore data for this Ligand-Target Pair
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LigandPNGBDBM50408479(CHEMBL5180503)
Affinity DataIC50:  1.70nMAssay Description:Antagonist activity at human P2X7 receptor transfected in THP1 cells assessed as inhibition of benzoyl-ATP-induced changes in plasma membrane pore fo...More data for this Ligand-Target Pair
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LigandPNGBDBM21691(1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridi...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of Escherichia coli DNA gyraseMore data for this Ligand-Target Pair
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LigandPNGBDBM50410546(CHEMBL26159)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory activity against Dihydrofolate reductase in Neisseria gonorrhoeaeMore data for this Ligand-Target Pair
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LigandPNGBDBM50448498(BMS-791325 | Beclabuvir)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of Hepatitis C virus genotype 3a NS3/NS4A proteaseMore data for this Ligand-Target Pair
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LigandPNGBDBM50241662(CHEMBL4104741)
Affinity DataIC50:  1.80nMAssay Description:Dissociation constant against VEGF (vascular endothelial growth factor) was determined.More data for this Ligand-Target Pair
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LigandPNGBDBM50193093(RGB-286638)
Affinity DataIC50:  2nMAssay Description:Blocking activity against Beta-1 adrenergic receptor in spontaneously beating guinea pig atrial preparationsMore data for this Ligand-Target Pair
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LigandPNGBDBM50512074(CHEMBL4575813)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at M3 receptor in Dunkin-Hartley guinea pig trachea assessed as inhibition of methacholine-induced airway smooth muscle contracti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Bcr-Abl T315I mutant (unknown origin)More data for this Ligand-Target Pair
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LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2nMAssay Description:Inhibition of Platelet-derived growth factor receptor in P19 cellsMore data for this Ligand-Target Pair
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LigandPNGBDBM50239946(CHEMBL4084368)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human PD-1/PD-L1 interactionMore data for this Ligand-Target Pair
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LigandPNGBDBM50608667(CHEMBL5271201)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as relaxation of pBR322 DNA by supercoiling assayMore data for this Ligand-Target Pair
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LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of C-terminal His6 tagged human full length CDK1/N-terminal GST-tagged human full length Cyclin B expressed in baculovirus infected Sf21 c...More data for this Ligand-Target Pair
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LigandPNGBDBM50404385(CHEMBL5273069)
Affinity DataIC50:  2.5nMAssay Description:In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.More data for this Ligand-Target Pair
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LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)
Affinity DataIC50:  2.70nMAssay Description:The compound was evaluated for its relative binding affinity against mutant N131A scytalone dehydratase; Relative KiMore data for this Ligand-Target Pair
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LigandPNGBDBM21690(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase assessed as relaxation of pBR322 DNA by supercoiling assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50239948(CHEMBL4071326 | US9850225, Example 1166)
Affinity DataIC50:  3nMAssay Description:Inhibition of C-terminal his tagged human PD-1/human Fc tagged PDL-1 interaction expressed in HEK293 cells incubated for 2 hrs AlphaScreen assayMore data for this Ligand-Target Pair
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