Found 39 of ic50 for monomerid = 14775 TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D [372-376,381-715,S375G,I381V,S383G,G384S,V385H,K386M)(Homo sapiens (Human))
Plexxikon
Plexxikon
Affinity DataIC50: 0.0210nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
3D Structure (crystal)TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human PDE4D by scintillation counting methodMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 0.0210nMAssay Description:Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of human PDE4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B [316-320,321-700,S319G,N320S,N321H,T322M](Homo sapiens (Human))
Plexxikon
Plexxikon
Affinity DataIC50: 0.0410nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of human His-tagged PDE4B catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 0.0410nMAssay Description:Inhibition of human PDE4B by scintillation counting methodMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against recombinant phosphodiesterase 4B (PDE4B) of human mononuclear lymphocytesMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 0.800nMAssay Description:Compound was evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4DMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human Phosphodiesterase 4BMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Phosphodiesterase 4 from human neutrophilsMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of PDE4 from guinea pig macrophagesMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Phosphodiesterase 4 (PDE4) from guinea pig macrophagesMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of phosphodiesterase type IV (PDE4) activityMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Phosphodiesterase type 4 (PDE4) from guinea-pig macrophageMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Concentration to inhibit 50% of Phosphodiesterase 4 (PDE-4) from guinea pig macrophagesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase type 4A (PDE4A).More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant PDE4DMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human His6-tagged PDE4B (152-487) expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
King'S College London
Curated by ChEMBL
King'S College London
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant PDE4BMore data for this Ligand-Target Pair
Affinity DataIC50: 3.80nMAssay Description:Evaluated in vitro for its inhibitory activity on unpurified recombinant Phosphodiesterase 4CMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant PDE4AMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Tanabe Seiyaku
Curated by ChEMBL
Tanabe Seiyaku
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibitory activity on human eosinophil phosphodiesterase 4.More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant PDE4CMore data for this Ligand-Target Pair
TargetIsoform 4 of Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A1) 35-489](Homo sapiens (Human))
Plexxikon
Plexxikon
Affinity DataIC50: 1.60E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 3.50E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 8.80E+3nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [432-779](Homo sapiens (Human))
Plexxikon
Plexxikon
Affinity DataIC50: 2.10E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
Affinity DataIC50: 5.40E+4nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetDual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B(Homo sapiens (Human))
Plexxikon
Plexxikon
Affinity DataIC50: 6.80E+4nMpH: 7.5 T: 2°CAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetHigh affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A(Homo sapiens (Human))
Plexxikon
Plexxikon
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [226-593](Homo sapiens (Human))
Plexxikon
Plexxikon
Affinity DataIC50: >2.00E+5nMAssay Description:Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-...More data for this Ligand-Target Pair
