Found 61 of ic50 for monomerid = 50049730 TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of crude aldose reductase of rat lensMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibitory activity measured against rat lens aldose reductase using 3-pyridinecarboxaldehyde as substrateChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:In vitro inhibitory activity of the compound against partially purified rat lens Aldose reductase at a dose of 5e-7MMore data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibitory activity against rat lens aldose reductase(AR).More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of N-terminal 6His-tagged human aldose reductase expressed in Escherichia coli BL21(DE3) mediated NADPH linked pyridine-3-aldehyde reducti...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibitory activity against purified rat lens aldose reductase (RLAR)More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of Wistar rat lens ALR2 using L-glyceraldehyde as substrate preincubated for 10 mins followed by substrate addition and measured for 4 min...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Kyushu University
Curated by ChEMBL
Kyushu University
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of human Protein kinase C beta 2More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Kyushu University
Curated by ChEMBL
Kyushu University
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of Protein kinase C zetaMore data for this Ligand-Target Pair
Affinity DataIC50: 45nMAssay Description:Inhibition of rat lens ALR2 using D,L-glyceraldehyde as substrate preincubated for 5 mins at 30 degC followed by substrate addition and measured afte...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of recombinant human ALR2 using D,L-glyceraldehyde and NADPH as substrate preincubated for 3 mins followed by substrate addition and measu...More data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of Sprague-Dawley rat lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of rat lens aldose reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of aldose reductase in rat lens homogenates by fluorophotometerMore data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of rat lens aldose reductase using DL-glyceraldehyde as substrate after 30 mins by fluorescence microplate reader analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 81nMAssay Description:Inhibition of AKR1B1 in rat lensesMore data for this Ligand-Target Pair
Affinity DataIC50: 84nMAssay Description:Inhibition of Wistar rat lenses ALR2 using D,L-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured after 5 mins b...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 85nMAssay Description:Inhibition of recombinant human ALR2 assessed as reduction in NADPH oxidation measured for 5 mins in presence of D,L-glyceraldehyde by spectrophotome...More data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:Inhibitory concentration against human erythrocytic purine nucleoside phosphorylase in the presence of 50 mM (pi) orthophosphonateMore data for this Ligand-Target Pair
Affinity DataIC50: 86nMAssay Description:Inhibition of Wistar rat ALR2 using D,L-glyceraldehyde as substrate assessed as oxidation of NADPH preincubated for 10 mins followed by substrate add...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 93.9nMAssay Description:Inhibition of human muscle recombinant aldose reductase by spectrophotometryMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of aldose reductase (unknown origin)More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant AKR1B1 expressed in Escherichia coli BL21 cells using pyridine-3-aldehyde as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of rat kidney NADPH-dependent aldose reductase assessed as DL-glyceraldehyde conversion to glycerol preincubated for 20 mins followed by N...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 102nMAssay Description:Inhibition of human recombinant aldose reductase expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in NADPH oxidation using L-idos...More data for this Ligand-Target Pair
Affinity DataIC50: 108nMAssay Description:Inhibition of Wistar rat lens ALR2 assessed as reduction in NADPH oxidation using D,L-glyceraldehyde and NADPH as substrate preincubated for 10 mins ...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of human Protein kinase C epsilonMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of Protein kinase C delta expressed in Sf-9 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 120nMAssay Description:Inhibition of Wistar rat eye lens aldose reductase-2 using D-L glyceraldehyde as substrate assessed as oxidation of NADPH preincubated for 10 mins fo...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of ALR2 from rat lens using D,L-glyceraldehyde as substrate measured as absorption of NADPH for 4 mins by UV/vis spectrophotmetryMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of Protein kinase C zetaMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of bovine aldose reductase assessed as oxidation of NADPHMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of bovine lens ALR2More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1 [K65Q](Bos taurus (Cattle))
University Of Messina
Curated by ChEMBL
University Of Messina
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of bovine lens aldose reductase assessed as inhibition of NDAPH oxidation by non-linear regression analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of Sprague-Dawley albino rat ALR2 assessed as enzyme-mediated oxidation of NADPH using D,L-glyceraldehyde as substrate by spectrophotometr...More data for this Ligand-Target Pair
Affinity DataIC50: 170nMAssay Description:Inhibition of Sprague-Dawley albino rat lens ALR2 by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 227nMAssay Description:Inhibition of ALR2 in Wistar rat eye lens assessed as reduction in NADPH consumption preincubated for 1 min followed by D,L-glyceraldehyde addition m...More data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of Wistar rat lens aldose reductase using D,L-glyceraldehyde as substrate incubated for 1 min measured for 4 mins by spectrophotometryMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Kyushu University
Curated by ChEMBL
Kyushu University
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of reductase activity of N-terminal 6His-tagged AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as inhibition of NADPH linked pyr...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B10(Homo sapiens (Human))
Kyushu University
Curated by ChEMBL
Kyushu University
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant N-His6-tagged AKR1B10 expressed in Escherichia coli BL21 cells using pyridine-3-aldehyde as substrate by spectrophotometryMore data for this Ligand-Target Pair
Affinity DataIC50: 510nMAssay Description:Inhibition of ALR2 in rat erythrocytes assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromat...More data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of ALR2 in rat lens assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chromatographic...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 620nMAssay Description:Inhibition of human recombinant ALR2 expressed in Escherichia coli using DL-glyceraldehyde as substrate and NADPH preincubated for 5 mins followed by...More data for this Ligand-Target Pair
Affinity DataIC50: 860nMAssay Description:Inhibition of ALR2 in rat sciatic nerve assessed as reduction in sorbitol accumulation incubated for 3 hrs in presence of 28 mM glucose by gas chroma...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B7(Rattus norvegicus)
Beijing Institute Of Technology
Curated by ChEMBL
Beijing Institute Of Technology
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of rat kidney ALR1 using sodium D-glucuronate as substrate preincubated for 4 mins at 37 degC followed by substrate addition and measured ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Invitro inhibitory activity of the compound against rat kidney Aldehyde reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member A1(Rattus norvegicus)
Nippon Zoki Pharmaceutical
Curated by ChEMBL
Nippon Zoki Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibitory activity against rat kidney aldehyde reductase(ALR).More data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Selectivity ratio measured as the IC50 ratio of aldehyde/aldose reductase valuesChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 2.26E+3nMAssay Description:Inhibition of Wistar rat kidney ALR1 using sodium D-glucuronate as substrate preincubated for 10 mins followed by substrate addition and measured for...More data for this Ligand-Target Pair
