Found 5 Enz. Inhib. hit(s) with Target = 'cAMP-specific 3',5'-cyclic phosphodiesterase 4B' and Ligand = 'BDBM50248919' TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Shijiazhuang Sagacity New Drug Development
US Patent
Shijiazhuang Sagacity New Drug Development
US Patent
Affinity DataIC50: 16.5nMAssay Description:The enzyme activity was indicated by measuring the AMP/GMP expression and tracing AMP/GMP antibody binding based on fluorescence polarization in the ...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Shijiazhuang Sagacity New Drug Development
US Patent
Shijiazhuang Sagacity New Drug Development
US Patent
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human His6-tagged PDE4B1 UCR1 S133D mutant expressed in baculovirus infected Sf9 insect cells using cAMP as substrate prein...More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Shijiazhuang Sagacity New Drug Development
US Patent
Shijiazhuang Sagacity New Drug Development
US Patent
Affinity DataIC50: 27nMAssay Description:Inhibition of PDE4B (unknown origin)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Shijiazhuang Sagacity New Drug Development
US Patent
Shijiazhuang Sagacity New Drug Development
US Patent
Affinity DataIC50: 30nMAssay Description:Inhibition of platelet derived growth factor receptor beta phosphorylation in MG63 cells in the presence of human plasmaMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Shijiazhuang Sagacity New Drug Development
US Patent
Shijiazhuang Sagacity New Drug Development
US Patent
Affinity DataIC50: 74nMAssay Description:Inhibition of human PDE4B using [3H]cAMP as substrate incubated for 5 mins followed by substrate addition and measured after 10 mins by scintillation...More data for this Ligand-Target Pair
