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Beta-1 adrenergic receptor(Homo sapiens (Human))
Janssen Research Foundation

Curated by PDSP K_i Database

Ki: 9.83E+3nM IC50: 1.70E+4nMpH: 7.4Assay Description:Human recombinant adrenergic β1 receptors expressed in CHO-K1 cells are used in modified Tris-HCl buffer pH 7.4. A 25 aliquot is incubated with ...More data for this Ligand-Target Pair

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Filter my 493 hits

Targets 2▿
- Beta-1 adrenergic receptor 487
- Beta-1/Beta-2/Beta-3 adrenergic receptor 6
Publications 50▿
- Bioorg Med Chem Lett 20: 6108-15 (2010) 43
- Bioorg Med Chem Lett 20: 5302-7 (2010) 35
- Bioorg Med Chem Lett 20: 3399-404 (2010) 33
- Bioorg Med Chem Lett 24: 2625-30 (2014) 29
- US Patent US10925840 (2021) 26
- Bioorg Med Chem Lett 24: 4341-7 (2014) 25
- J Med Chem 61: 5380-5394 (2018) 21
- Naunyn Schmiedebergs Arch Pharmacol 369: 151-9 (2004) 20
- Bioorg Med Chem Lett 17: 4290-6 (2007) 18
- Bioorg Med Chem Lett 17: 5245-50 (2007) 17
- J Med Chem 62: 7806-7839 (2019) 17
- J Pharmacol Exp Ther 303: 791-804 (2002) 14
- J Pharmacol Exp Ther 270: 665-74 (1994) 14
- J Med Chem 36: 157-61 (1993) 13
- Psychopharmacology (Berl) 124: 57-73 (1996) 12
- Bioorg Med Chem Lett 7: 1583-1588 (1997) 10
- Bioorg Med Chem Lett 22: 6280-5 (2012) 10
- J Med Chem 44: 1456-66 (2001) 8
- Bioorg Med Chem 15: 2533-43 (2007) 7
- Bioorg Med Chem Lett 6: 2253-2258 (1996) 7
- Bioorg Med Chem Lett 17: 1033-6 (2007) 7
- J Med Chem 42: 2287-94 (1999) 5
- ACS Med Chem Lett 10: 1436-1442 (2019) 5
- J Med Chem 62: 3753-3772 (2019) 4
- Bioorg Med Chem Lett 14: 5963-6 (2004) 4
- Bioorg Med Chem Lett 14: 5959-62 (2004) 4
- J Med Chem 39: 3701-11 (1996) 4
- Bioorg Med Chem Lett 7: 25-30 (1997) 4
- Bioorg Med Chem Lett 17: 5600-4 (2007) 3
- Bioorg Med Chem Lett 11: 981-4 (2001) 3
- Bioorg Med Chem Lett 21: 5506-9 (2011) 3
- Bioorg Med Chem 27: 2959-2971 (2019) 3
- J Med Chem 61: 3712-3725 (2018) 3
- J Med Chem 45: 4344-9 (2002) 3
- J Med Chem 56: 3444-5 (2013) 2
- Bioorg Med Chem 18: 8600-13 (2010) 2
- J Med Chem 55: 2406-15 (2012) 2
- ACS Med Chem Lett 13: 648-657 (2022) 2
- Bioorg Med Chem Lett 13: 4421-5 (2003) 2
- Bioorg Med Chem Lett 12: 2963-7 (2002) 2
- Bioorg Med Chem 18: 728-36 (2010) 2
- J Med Chem 62: 9658-9679 (2019) 2
- J Med Chem 53: 6386-97 (2010) 2
- Psychopharmacology (Berl) 157: 111-4 (2001) 2
- J Med Chem 49: 3116-35 (2006) 1
- Bioorg Med Chem Lett 22: 2434-9 (2012) 1
- Bioorg Med Chem Lett 20: 628-31 (2010) 1
- Bioorg Med Chem Lett 20: 4932-5 (2010) 1
- Eur J Pharmacol 423: 71-83 (2001) 1
- Eur J Med Chem 151: 557-567 (2018) 1
- ...
Institutions 39▿
- 4Sc 76
- Novartis Institutes For Biomedical Research 70
- Theravance 29
- The Usa, As Represented By The Secretary, Department of Health and Human Services 26
- TBA 21
- University of Florence 21
- Università 20
- Pfizer 20
- UniversitÄT WÜRzburg 20
- Bristol-Myers Squibb Pharmaceutical Research Institute 18
- University of Copenhagen 17
- Ohio State University 14
- Institut De Recherches Servier 14
- Janssen Research Foundation 13
- Wyeth-Ayerst Research 11
- Dainippon Pharmaceutical 8
- Glaxosmithkline 7
- University of Tennessee 5
- University of Minnesota Twin Cities 5
- University of Tennessee-Memphis 4
- University of North Carolina At Chapel Hill 4
- Eli Lilly 3
- Purdue University 3
- Universit£ 3
- University Of Toronto 3
- Friedrich-Alexander Universit£T Erlangen-N£Rnberg 3
- Drug Discovery Laboratory 2
- Virginia Commonwealth University 2
- Friedrich-Alexander-Universit£T Erlangen-N£Rnberg 2
- Northwestern University 2
- Case Western Reserve University 2
- Medical University Of Lublin 2
- Wyeth Research 2
- H. Lundbeck 2
- National Institute Of Mental Health 2
- Predix Pharmaceuticals 1
- Hunter College And The Graduate Center Of The City University Of New York 1
- University of Texas At Austin 1
- Sk Biopharmaceuticals 1
- ...
Affinity: 0.020 to 1.0E+8 nM▿
- Ki 493
- IC50 1
- Affinity ≤ nM
Xtal structures: 4
Docked structures: 0
Catalog Cmpds: 106