Affinity DataEC50: 5.60nMAssay Description:Agonist activity at human recombinant mGlu2 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1.5 hrs by FLIPR assa...More data for this Ligand-Target Pair
Affinity DataEC50: 129nMAssay Description:Agonist activity at human recombinant mGlu3 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: 48nMAssay Description:Agonist activity at human recombinant mGlu2 receptor E273D and L300Q mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: 5.68E+3nMAssay Description:Agonist activity at wild type human recombinant mGlu3 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLI...More data for this Ligand-Target Pair
Affinity DataEC50: 2.18E+3nMAssay Description:Agonist activity at human recombinant mGlu3 receptor D279E mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.83E+3nMAssay Description:Agonist activity at human recombinant mGlu3 receptor Q306L mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.18E+3nMAssay Description:Agonist activity at human recombinant mGlu3 receptor D279E and Q306L mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization afte...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu1 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu4 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu5 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.45E+3nMAssay Description:Agonist activity at human recombinant mGlu6 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu7 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.01E+4nMAssay Description:Agonist activity at human recombinant mGlu8 receptor expressed in AV12 cells assessed as inhibition of forskolin-stimulated cAMP production after 1 h...More data for this Ligand-Target Pair
Affinity DataEC50: >2.50E+4nMAssay Description:Agonist activity at human recombinant mGlu8 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1.5 hrs by FLIPR assa...More data for this Ligand-Target Pair
Affinity DataEC50: 20nMAssay Description:Agonist activity at wild type human recombinant mGlu2 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLI...More data for this Ligand-Target Pair
Affinity DataEC50: 46nMAssay Description:Agonist activity at human recombinant mGlu2 receptor E273D mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 22nMAssay Description:Agonist activity at human recombinant mGlu2 receptor L300Q mutant expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by ...More data for this Ligand-Target Pair
Affinity DataEC50: 21nMAssay Description:Agonist activity at human recombinant mGlu2 receptor expressed in AV12 cells assessed as stimulation of Ca2+ mobilization after 1 hr by FLIPR assayMore data for this Ligand-Target Pair