Affinity DataEC50: 0.0600nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0800nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 190nM EC50: 0.120nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0950nM EC50: 0.200nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0950nM EC50: 0.200nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.150nM EC50: 0.280nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.470nMAssay Description:Binding affinity to TRbeta1More data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 770nM EC50: 0.520nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to i...More data for this Ligand-Target Pair
Affinity DataIC50: 800nM EC50: 0.700nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to i...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nM EC50: 0.730nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
Affinity DataIC50: 0.270nM EC50: 0.770nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nM EC50: 0.780nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 1.50E+3nM EC50: 0.800nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to i...More data for this Ligand-Target Pair
Affinity DataEC50: 0.880nMAssay Description:Human epithelial kidney cells (HEK 293) were grown to 80% confluency in Dubelcco's modified Eagles 4.5 g/L glucose medium (high glucose DMEM) con...More data for this Ligand-Target Pair
Affinity DataIC50: 360nM EC50: 1nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to i...More data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at human THRbeta transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase activ...More data for this Ligand-Target Pair
Affinity DataEC50: 1.12nMAssay Description:Agonist activity at human thyroid hormone receptor beta expressed in CV1 cells by TRE-luciferase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.710nM EC50: 1.20nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
Affinity DataEC50: 1.24nMAssay Description:Human epithelial kidney cells (HEK 293) were grown to 80% confluency in Dubelcco's modified Eagles 4.5 g/L glucose medium (high glucose DMEM) con...More data for this Ligand-Target Pair
Affinity DataEC50: 1.49nMAssay Description:Human epithelial kidney cells (HEK 293) were grown to 80% confluency in Dubelcco's modified Eagles 4.5 g/L glucose medium (high glucose DMEM) con...More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Effective concentration of the compound binding towards TRbeta1 in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Half-maximum activation of human Thyroid hormone receptor beta 1 (hTRbeta1)More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Agonist activity at human recombinant TRbeta1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:TRE-driven dual-luciferase reporter assay in human uterine cervical cancer (Hela) cell lineMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Effect on human TRbeta transactivation activity in HeLa cells by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.5nMAssay Description:Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotin...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nM EC50: 2.60nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 2.82nMAssay Description:Human epithelial kidney cells (HEK 293) were grown to 80% confluency in Dubelcco's modified Eagles 4.5 g/L glucose medium (high glucose DMEM) con...More data for this Ligand-Target Pair
Affinity DataEC50: 2.90nMAssay Description:Binding affinity to TRbeta1More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.20nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.40nMAssay Description:Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotin...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nM EC50: 3.5nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRbeta. EC50 is the concentration of compound required to r...More data for this Ligand-Target Pair
Affinity DataEC50: 3.5nMAssay Description:Efficacy against TRAF-beta-1 reporter cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4.20nMAssay Description:Efficacy against TRAF-beta-1 reporter cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4.30nMAssay Description:Efficacy against TRAF-beta-1 reporter cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4.70nMAssay Description:Efficacy against TRAF-beta-1 reporter cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 5.10nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 5.5nMAssay Description:Huh7 cells were cultured in a DMEM medium supplemented with 10% FBS. The cells were inoculated into a 10 cm cell culture dish, proliferated to about ...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataEC50: 6.80nMAssay Description:Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotin...More data for this Ligand-Target Pair
Affinity DataEC50: 6.90nMAssay Description:Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotin...More data for this Ligand-Target Pair
