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Found 3991 of ic50 for UniProtKB: P56524
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50:  0.0800nMAssay Description:Inhibition of recombinant human HDAC4 using fluorogenic substrate by fluorescence microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366693(CHEMBL1793812)
Affinity DataIC50: <0.100nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Orchid Chemicals & Pharmaceuticals

LigandPNGBDBM65470(Quinolone-based HDAC inhibitor 4i)
Affinity DataIC50:  0.100nMAssay Description:Histone Deacetylase (HDAC) Inhibition Assay using Boc-Lys(Ac)-AMC Substrate: Inhibition of HDAC has been implicated to modulate transcription and to ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218940(CHEMBL1793991)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366738(CHEMBL1793985)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366696(CHEMBL1793811)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366712(CHEMBL1793822)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50134803(5,8-Dimethyl-11-(6-oxiranyl-6-oxo-hexyl)-decahydro...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of Histone deacetylase 4 in mammalian cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50588303(CHEMBL5170036)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50588302(CHEMBL5199116)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366713(CHEMBL1793816)
Affinity DataIC50:  0.400nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of human HDAC4 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50105327(JNJ-26481585 | Quisinostat)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of HDAC4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162854(US9056843, 145)
Affinity DataIC50:  0.75nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162865(US9056843, 156)
Affinity DataIC50:  0.850nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50:  0.970nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50531374(CHEMBL4467135)
Affinity DataIC50:  1nMAssay Description:Inhibition of HDAC (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50048864(CHEMBL3310505)
Affinity DataIC50:  1nMAssay Description:Inhibition of partially purified HDAC isolated from human M8 cells enzyme fraction pre-incubated for 5 mins before [3H]acetylated histone addition an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162848(US9056843, 139)
Affinity DataIC50:  1nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50141381(CHEMBL3758184)
Affinity DataIC50:  1nMAssay Description:Inhibition of HDAC in human HeLa cells nuclear extract using Fluor de lys as substrate after 15 mins by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218877(CHEMBL1793823)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366706(CHEMBL1793810)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataIC50:  1nMAssay Description:Inhibition of flag-tagged HDAC4 by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218879(CHEMBL1793947)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM25146(2-(5-methoxy-2-methyl-1H-indol-3-yl)-N-[(1S)-7-oxo...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50258539((S)-1-methyl-N-(1-(5-(naphthalen-2-yl)-1H-imidazol...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)
Affinity DataIC50: >1nMAssay Description:Inhibition of HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50:  1nMAssay Description:Inhibition of flag-tagged HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162859(US9056843, 150)
Affinity DataIC50:  1.10nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of flag-tagged HDAC4 by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162852(US9056843, 143)
Affinity DataIC50:  1.20nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of flag-tagged HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50268097(6-{[2-(9H-Fluoren-9-yliden)acetyl]amino}-N-hydroxy...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant HDAC4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218931(CHEMBL1793992)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50079798(CHEMBL99661)
Affinity DataIC50:  1.40nMAssay Description:Concentration required to inhibit Histone Deacetylase (HDAC) from K562 erythroleukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162850(US9056843, 141)
Affinity DataIC50:  1.40nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1/11/4/6/8(Homo sapiens (Human))
Orchid Chemicals & Pharmaceuticals

LigandPNGBDBM65471(Quinolone-based HDAC inhibitor 4j)
Affinity DataIC50:  1.5nMAssay Description:Histone Deacetylase (HDAC) Inhibition Assay using Boc-Lys(Ac)-AMC Substrate: Inhibition of HDAC has been implicated to modulate transcription and to ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222728(CHEMBL394261 | cyclo(-L-Am7(S2Py)-A2in-L-Ala-D-Pro...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222736(CHEMBL241555 | cyclo(-L-Am7(S2Py)-Aib-L-Ser(Bzl)-D...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162855(US9056843, 146)
Affinity DataIC50:  1.60nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478829(6-(6-Methoxynaphthalyl)Triazolylhexahydroxamic Aci...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human HDAC in HeLa cells by flour de lys assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM162860(US9056843, 151)
Affinity DataIC50:  1.80nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM50222732((5S,11S,13aR)-5-benzyl-8,8-dimethyl-11-[5-(pyridin...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50478811(6-(3-Biphenyl)Triazolylhexahydroxamic Acid | CHEMB...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human HDAC in HeLa cells by flour de lys assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366745(CHEMBL1793989)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) enzyme derived from partially purified extracts of human HeLa cells using [3H]11 as radioligan...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50218869(CHEMBL1793938)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity against histone deacetylase (HDAC) derived from partially purified extracts of human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Stony Brook University

Curated by ChEMBL
LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human HDAC4 expressed in 293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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