Compile Data Set for Download or QSAR
maximum 50k data
Found 42 of ic50 for UniProtKB: P08581
TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM605730(US11673897, Compound 82 | l-N'-[6-[(6,7-dimethoxy-...)
Affinity DataIC50: <10nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM610013(1-N'-(4-fluorophenyl)-1- N-[4-[7-methoxy-6-[[(2R)-...)
Affinity DataIC50: <10nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM610015(1-N-[4-[(6,7-dimethoxy- 1,5-naphthyridin-4- yl)oxy...)
Affinity DataIC50: <10nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM605727(1-N-(4-fluorophenyl)-1-N'-[6-[7- methoxy-6-(1H-pyr...)
Affinity DataIC50: <10nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM605726(1-N'-[6-(6-carbamoyl-7- methoxyquinolin-4-yl)oxy-5...)
Affinity DataIC50: <10nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609983(1-N'-[3-chloro-4-(6,7- dimethoxypyrido[3,2- d]pyri...)
Affinity DataIC50: <10nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM610018(1-N'-[4-[(6,7-dimethoxy- 1,5-naphthyridin-4-yl)oxy...)
Affinity DataIC50: <10nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM605721(US11673897, Compound 11 | methyl 4-[3-chloro-5-[[1...)
Affinity DataIC50: <10nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM605720(US11673897, Compound 10 | methyl 4-[5-[[1-[(4- flu...)
Affinity DataIC50: <10nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM610019(1-N'-[3-chloro-4-[(6,7- dimethoxy- 1,5-naphthyridi...)
Affinity DataIC50: <10nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM605724(1-N'-[6-(6-carbamoyl-7- methoxyquinolin-4-yl)oxypy...)
Affinity DataIC50: <10nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609993(1-N'-[3-chloro-4-[6-methoxy- 7-(3-morpholin-4- ylp...)
Affinity DataIC50: <10nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609994(1-N'-[3-fluoro-4-[6-methoxy- 7-(3-morpholin-4- ylp...)
Affinity DataIC50: <10nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM609984(1-N'-[4-(6,7- dimethoxypyrido[3,2- d]pyrimidin-4-y...)
Affinity DataIC50: <10nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609991(1-N'-(4-fluorophenyl)-1-N- [4-[6-methoxy-7-(3- mor...)
Affinity DataIC50:  55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM609982(1-N-[4-(6,7-dimethoxy- pyrido[3,2-d]pyrimidin- 4-y...)
Affinity DataIC50:  55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609981(1-N'-(4-fluorophenyl)-1- N-[4-(7-methoxy- pyrido[3...)
Affinity DataIC50:  55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM610007(1-N'-(4-fluorophenyl)-1-N- [4-[7-methoxy-6-(oxetan...)
Affinity DataIC50:  55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM605729(1-N'-[6-[(6,7-dimethoxy-1,5- naphthyridin-4-yl)oxy...)
Affinity DataIC50:  55nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM605728(1-N'-[5-chloro-6-[(6,7-dimethoxy- 1,5-naphthyridin...)
Affinity DataIC50:  55nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM605725(1-N-(4-fluorophenyl)-1-N'-[6-[7- methoxy-6- (methy...)
Affinity DataIC50:  55nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM605723(4-[3-chloro-5-[[1-[(4- fluorophenyl)carbamoyl]cycl...)
Affinity DataIC50:  55nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM610013(1-N'-(4-fluorophenyl)-1- N-[4-[7-methoxy-6-[[(2R)-...)
Affinity DataIC50:  55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM610010(1-N'-(4-fluorophenyl)-1-N- [4-[7-methoxy-6-(2-pyrr...)
Affinity DataIC50:  55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM610009(1-N-[4-(6-carbamoyl-7- methoxyquinazolin-4- yl)oxy...)
Affinity DataIC50:  55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM610008(1-N-[4-[6- (cyclopropylcarbamoyl)-7- methoxyquinaz...)
Affinity DataIC50:  55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM610005(1-N'-(4-fluorophenyl)-1-N- [4-(7-methoxypyrido[4,3...)
Affinity DataIC50:  55nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM609998(1-N-[4-(6-chloropyrido[3,4- d]pyrimidin-4-yl)oxy- ...)
Affinity DataIC50:  75nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM610006(1-N-[4-(6-cyanoquinazolin- 4-yl)oxyphenyl]-1-N'-(4...)
Affinity DataIC50:  75nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609990(1-N-[4-(6-cyano-7- methoxypyrido[3,2- d]pyrimidin-...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609989(1-N'-(4-fluorophenyl)-1- N-[4-(6,7,8,9-tetrahydro-...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM610002(1-N'-(4-fluorophenyl)-1-N- [4-(6-methoxypyrido[3,4...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM610012(US11708367, Compound 120 | tert-butyl (2S)-2-[[[4-...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM610004(1-N-[4-(7-chloropyrido[4,3- d]pyrimidin-4-yl)oxy- ...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609980(1-N-[4-(7-bromopyrido[3,2- d]pyrimidin-4-yl)oxyphe...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609979(1-N-[4-(7-chloropyrido[3,2- d]pyrimidin-4-yl)oxyph...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM605722(4-[5-[[l-[(4- fluorophenyl)carbamoyl]cyclo- propan...)
Affinity DataIC50:  550nMAssay Description:Human Met (residues R974-S1390 with A1209G and V1290L, 3.4 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 250 μM KKKGQEEEYVFIE (SEQ ID NO...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM610003(1-N'-(4-fluorophenyl)-1- N-(4-pyrido[4,3-d]pyrimid...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609986(1-N-[4-(6,7-dimethyl- pyrido[3,2-d]pyrimidin- 4-yl...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
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US Patent
LigandPNGBDBM609997(1-N'-(4-fluorophenyl)-1-N- (4-pyrido[3,4-d]pyrimid...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM609978(1-N'-(4-fluorophenyl)-1- N-(4-pyrido[3,2-d]pyrimid...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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TargetHepatocyte growth factor receptor [974-1390,A1209G,V1290L](Homo sapiens (Human))
Exelixis

US Patent
LigandPNGBDBM610011(US11708367, Compound 119 | tert-butyl (2R)-2-[[[4-...)
Affinity DataIC50:  550nMAssay Description:Human KDR (residues K790-V1356, 55 nM) was incubated with 8 mM MOPS pH 7.0, 0.2 mM EDTA, 0.33 mg/mL myelin basic protein, 10 mM magnesium acetate, an...More data for this Ligand-Target Pair
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