Compile Data Set for Download or QSAR
maximum 50k data
Found 116 of ic50 for UniProtKB: P22906
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM18043(1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QU...)
Affinity DataIC50:  4nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM18047(5-[(4-TERT-BUTYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDI...)
Affinity DataIC50:  8nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298811((S)-5-(3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)bu...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50429695(CHEMBL2335421)
Affinity DataIC50:  17nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298810((R)-5-(3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)bu...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298801((+/-)-5-(3-(5-methoxy-3',5'-dimethylbiphenyl-3-yl)...)
Affinity DataIC50:  17nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM26521(6-ethyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-y...)
Affinity DataIC50:  18nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50007898(CHEMBL3234317)
Affinity DataIC50:  18nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298812((R)-6-ethyl-5-(3-(3,4,5-trimethoxyphenyl)but-1-yny...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298813((S)-6-ethyl-5-(3-(3,4,5-trimethoxyphenyl)but-1-yny...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298805((+/-)-6-ethyl-5-(3-(3,4,5-trimethoxyphenyl)but-1-y...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50329607(5-(3-(3-methoxybiphenyl-4-yl)but-1-ynyl)-6-methylp...)
Affinity DataIC50:  20nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50429700(CHEMBL2335416)
Affinity DataIC50:  21nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298814((R)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-y...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298815((S)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1-y...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298800((+/-)-5-(3-(5-methoxy-4'-methylbiphenyl-3-yl)but-1...)
Affinity DataIC50:  22nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50429693(CHEMBL2335423)
Affinity DataIC50:  23nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50007902(CHEMBL3234321)
Affinity DataIC50:  23nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50429699(CHEMBL2335417)
Affinity DataIC50:  23nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM18046(5-((4-methylphenyl)thio)-quinazoline 2,4-diamine, ...)
Affinity DataIC50:  23nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298817(5-((3S)-3-(2-methoxy-2'-methylbiphenyl-4-yl)but-1-...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM25823(5-{3-[3-methoxy-4-(2-methylphenyl)phenyl]but-1-yn-...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298816(5-((3R)-3-(2-methoxy-2'-methylbiphenyl-4-yl)but-1-...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298809((+/-)-5-(3-(4',5-dimethoxybiphenyl-3-yl)but-1-ynyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298819((S)-5-(3-(4',5-dimethoxybiphenyl-3-yl)but-1-ynyl)-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50007817(CHEMBL3234115)
Affinity DataIC50:  30nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298818((R)-5-(3-(4',5-dimethoxybiphenyl-3-yl)but-1-ynyl)-...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM25824(5-{3-[4-(2,6-dimethylphenyl)-3-methoxyphenyl]but-1...)
Affinity DataIC50:  32nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298821((S)-5-(3-(2-methoxy-2',6'-dimethylbiphenyl-4-yl)bu...)
Affinity DataIC50:  32nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298820((R)-5-(3-(2-methoxy-2',6'-dimethylbiphenyl-4-yl)bu...)
Affinity DataIC50:  32nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50007819(CHEMBL3234117)
Affinity DataIC50:  33nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50329608(6-methyl-5-(3-methyl-3-(3,4,5-trimethoxyphenyl)but...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Candida albicans DHFRMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM25826(5-[(3R)-3-(3-methoxy-5-phenylphenyl)but-1-yn-1-yl]...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298804((+/-)-6-methyl-5-(4-methyl-3-(3,4,5-trimethoxyphen...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298802((+/-)-5-(3-(4'-tert-butyl-5-methoxybiphenyl-3-yl)b...)
Affinity DataIC50:  34nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298823((S)-5-(3-(3'-tert-butyl-5-methoxybiphenyl-3-yl)but...)
Affinity DataIC50:  34nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298822((R)-5-(3-(4'-tert-butyl-5-methoxybiphenyl-3-yl)but...)
Affinity DataIC50:  34nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM18045(5-(PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE | 5-(phe...)
Affinity DataIC50:  34nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50329613(5-(3-(2,5-dimethoxybiphenyl-4-yl)but-1-ynyl)-6-met...)
Affinity DataIC50:  36nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM25827(5-[(3S)-3-(3-methoxy-5-phenylphenyl)but-1-yn-1-yl]...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50007905(CHEMBL3234324)
Affinity DataIC50:  37nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM25821(5-(3-{3-[2,6-bis(propan-2-yl)phenyl]-5-methoxyphen...)
Affinity DataIC50:  38nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298824((R)-5-(3-(2',6'-diisopropyl-5-methoxybiphenyl-3-yl...)
Affinity DataIC50:  38nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298825((S)-5-(3-(2',6'-diisopropyl-5-methoxybiphenyl-3-yl...)
Affinity DataIC50:  38nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50007820(CHEMBL3234118)
Affinity DataIC50:  39nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298827((S)-5-(3-(2',6'-diisopropyl-2-methoxybiphenyl-4-yl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM25825(5-(3-{4-[2,6-bis(propan-2-yl)phenyl]-3-methoxyphen...)
Affinity DataIC50:  41nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50298826((R)-5-(3-(2',6'-diisopropyl-2-methoxybiphenyl-4-yl...)
Affinity DataIC50:  41nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
Gsk

LigandPNGBDBM50007901(CHEMBL3234320)
Affinity DataIC50:  43nMAssay Description:Inhibition of Candida albicans DHFR using dihydrofolate as substrate preincubated for 5 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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