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Found 3865 of ic50 for UniProtKB: P31645
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50145347(1-(2-(4-(6-fluoro-1H-indol-3-yl)-5,6-dihydropyridi...)
Affinity DataIC50:  0.110nMAssay Description:Inhibitory concentration against serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50295294((+/-)-trans-3-(2-((dimethylamino)methyl)cyclopenty...)
Affinity DataIC50:  0.130nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50295294((+/-)-trans-3-(2-((dimethylamino)methyl)cyclopenty...)
Affinity DataIC50:  0.130nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50124562(1-[3-(4-isopropenylphenyl)-(2S,3S)-8-azabicyclo[3....)
Affinity DataIC50:  0.160nMAssay Description:Binding affinity towards serotonin transporter (SERT) by using [3H]-paroxetine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50028094((1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-te...)
Affinity DataIC50:  0.190nMAssay Description:Inhibition of SERT (unknown origin)More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [125I]RTI-55 from human recombinant SERT expressed in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50330813(3-[(1S,3R)-3-Dimethylaminocyclopentyl]-1H-indole-5...)
Affinity DataIC50:  0.220nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50278521((S)-N-butyl-N-(naphthalen-2-ylmethyl)pyrrolidin-3-...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of radiolabeled serotonin reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM84745(CAS_136434-34-9 | DULOXETINE | LY-248686 | LY24868...)
Affinity DataIC50:  0.316nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50295294((+/-)-trans-3-(2-((dimethylamino)methyl)cyclopenty...)
Affinity DataIC50:  0.320nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50295294((+/-)-trans-3-(2-((dimethylamino)methyl)cyclopenty...)
Affinity DataIC50:  0.320nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50124569(1-[3-(4-vinylphenyl)-(2S,3S)-8-azabicyclo[3.2.1]oc...)
Affinity DataIC50:  0.320nMAssay Description:Binding affinity towards serotonin transporter (SERT) by using [3H]-paroxetine as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50209166(3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole-5-c...)
Affinity DataIC50:  0.340nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50246181((2-(3,4-dichlorophenoxy)phenyl)-N,N-dimethylmethan...)
Affinity DataIC50:  0.350nMAssay Description:Inhibition of serotonin reuptake at SERT (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataIC50:  0.360nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataIC50:  0.360nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50124565(CHEMBL353333 | methyl 3-(4-iodophenyl)-(2S,3S)-8-a...)
Affinity DataIC50:  0.360nMAssay Description:Binding affinity towards serotonin transporter (SERT)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50330844(3-[(1R,3S)-3-Dimethylaminocyclopentyl]-1H-indole-5...)
Affinity DataIC50:  0.380nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50209168((R)-3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of SERT (unknown origin) in HEK293 cells assessed as inhibition of 5-HT reuptake by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of SERT (unknown origin) expressed in human HEK293 cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50151982(5-{4-[4-(5-Cyano-1H-indol-3-yl)-butyl]-piperazin-1...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of SERT (unknown origin) expressed in HEK293 cells assessed as reduction in 5-HT uptake incubated for 30 minsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataIC50:  0.480nMAssay Description:Inhibition of human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50330813(3-[(1S,3R)-3-Dimethylaminocyclopentyl]-1H-indole-5...)
Affinity DataIC50:  0.480nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataIC50:  0.480nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50490602(CHEMBL2338047)
Affinity DataIC50:  0.501nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50173715((+)3-((1S,2S)-2-Dimethylaminomethyl-cyclopropyl)-1...)
Affinity DataIC50:  0.560nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50209172((S)-3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole...)
Affinity DataIC50:  0.560nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataIC50:  0.560nMAssay Description:Inhibition of human SERT expressed in CHO cell membranes assessed as reduction in [3H]serotonin uptake preincubated for 10 mins followed by [3H]serot...More data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50330814(CHEMBL1275791 | [(1R,3S)-3-(5-Fluoro-1H-indol-3-yl...)
Affinity DataIC50:  0.630nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50490607(CHEMBL2338037)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50490636(CHEMBL2337599)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50352717(CHEMBL1823213 | US8835436, Example 151)
Affinity DataIC50:  0.640nMpH: 7.4Assay Description:For serotonin transporter binding assays, a reaction mixture with a final volume of 0.25 ml was prepared by mixing a test compound, human serotonin t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50352717(CHEMBL1823213 | US8835436, Example 151)
Affinity DataIC50:  0.640nMAssay Description:Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50459917(CHEMBL4228747)
Affinity DataIC50:  0.720nMAssay Description:Binding affinity to SERT (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50209168((R)-3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole...)
Affinity DataIC50:  0.720nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50209168((R)-3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole...)
Affinity DataIC50:  0.720nMAssay Description:Displacement of [125I]RTI-55 from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50209168((R)-3-(4-(dimethylamino)cyclohex-1-enyl)-1H-indole...)
Affinity DataIC50:  0.720nMAssay Description:Displacement of [I125]RTI-55 from human SERT transfected in human HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50352719(CHEMBL1823215 | US8835436, Example 152)
Affinity DataIC50:  0.75nMpH: 7.4Assay Description:For serotonin transporter binding assays, a reaction mixture with a final volume of 0.25 ml was prepared by mixing a test compound, human serotonin t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50352719(CHEMBL1823215 | US8835436, Example 152)
Affinity DataIC50:  0.75nMAssay Description:Displacement of [3H]impiramine from human serotonin transporter membrane expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50490626(CHEMBL2337608)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50490612(CHEMBL2337603)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Affinity DataIC50:  0.880nMAssay Description:Displacement of [3H]imipramine from human recombinant 5HT transporter expressed in CHO cells measured after 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Affinity DataIC50:  0.880nMAssay Description:Displacement of [3H]imipramine from human recombinant 5-HT transporter expressed in CHO cellsMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50330843(3-[(1S,3S)-3-Dimethylaminocyclopentyl]-1H-indole-5...)
Affinity DataIC50:  0.970nMAssay Description:Binding affinity to human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50490637(CHEMBL2338049)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant SERT expressed in HEK293 cells assessed as inhibition of [3H]5HT reuptakeMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50209175(CHEMBL396537 | N,N-dimethyl-4-(5-nitro-1H-indol-3-...)
Affinity DataIC50:  1nMAssay Description:Displacement of [3H]citalopram from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50178374(((5S,8S)-5-(3,4-dichlorophenyl)-8-(methylamino)-5,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of serotonin re-uptake at human serotonin transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50178367((5S,8S)-5-(3,4-dichlorophenyl)-8-(methylamino)-5,6...)
Affinity DataIC50:  1nMAssay Description:Inhibition of serotonin re-uptake at human serotonin transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Organon Laboratories

Curated by ChEMBL
LigandPNGBDBM50252172(5-(3,4-dichlorophenyl)-8-(methylamino)-5,6,7,8-tet...)
Affinity DataIC50:  1nMAssay Description:Inhibition of [3H]5HT reuptake at human serotonin transporter expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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