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Found 26 of ic50 for UniProtKB: P47747
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50036754((1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)...)
Affinity DataIC50:  300nMAssay Description:Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atriumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213876(CHEMBL50524)
Affinity DataIC50:  442nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50020712(10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...)
Affinity DataIC50:  660nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213878(CHEMBL301294)
Affinity DataIC50:  684nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM77970(3-(2-chloranyl-5,6-dihydrobenzo[b][1]benzazepin-11...)
Affinity DataIC50:  720nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213879(CHEMBL298354)
Affinity DataIC50:  747nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213959(CHEMBL50294)
Affinity DataIC50:  809nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM31005(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Affinity DataIC50:  880nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM22889((Cimetidine) N-Methyl-N''''-[2-(5-methyl-1H-imidaz...)
Affinity DataIC50:  1.02E+3nMAssay Description:Inhibition of guinea pig histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213877(CHEMBL50523)
Affinity DataIC50:  1.05E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213880(CHEMBL50503)
Affinity DataIC50:  1.14E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213960(CHEMBL49928)
Affinity DataIC50:  1.27E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50036755(CHEMBL556048 | N-[6-(2-Guanidino-thiazol-4-yl)-pyr...)
Affinity DataIC50:  1.30E+3nMAssay Description:Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atriumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50079527((3E)-3-dibenzo[b,e]oxepin-11(6H)-ylidene-N,N-dimet...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213875(CHEMBL52637)
Affinity DataIC50:  1.83E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50010859(CHEMBL11 | IMIPRAMINE HYDROCHLORIDE | IMIPRAMINE P...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50213958(CHEMBL298928)
Affinity DataIC50:  1.93E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50103506(Ranitidine | Tritec | Zantac)
Affinity DataIC50:  3.33E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM22893(CHEMBL512 | Ranitidine | ZANTAC | dimethyl[(5-{[(2...)
Affinity DataIC50:  3.40E+3nMAssay Description:Compound was tested for H2 receptor antagonistic activity against histamine stimulated chronotropic response in isolated guinea pig right atriumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM31005(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)
Affinity DataIC50:  3.80E+3nMAssay Description:In vitro antihistamine activity by activation of 4-methylhistamine mediated by Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50404032(ROXATIDINE ACETATE)
Affinity DataIC50:  4.10E+3nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM112777(NORTRIPTYLINE | US8629135, SW-02)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50027226(3-Methyl-1,2,3,4,4a,8-hexahydro-7-thia-3,12b-diaza...)
Affinity DataIC50:  7.20E+3nMAssay Description:In vitro antihistamine activity by activation of 4-methylhistamine mediated by Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50103595(Brumetadina | CHEBI:3699 | Cimetidine | Tagamet | ...)
Affinity DataIC50:  1.46E+4nMAssay Description:Histamine H2 receptor antagonistic activityMore data for this Ligand-Target Pair
In DepthDetails
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Fujisawa Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50027227(3-Methyl-1,2,3,4,4a,8-hexahydro-5-thia-3,12b-diaza...)
Affinity DataIC50:  1.90E+4nMAssay Description:In vitro antihistamine activity by activation of 4-methylhistamine mediated by Histamine H2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed