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Found 27 of ic50 for UniProtKB: P47869
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337263(3-(2-chlorobenzyloxy)-2-(2-fluorophenyl)-2H-pyrazo...)
Affinity DataIC50:  2nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM84957(CGS 9896 | CHEMBL20042)
Affinity DataIC50:  4nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50608946(CHEMBL2008708)
Affinity DataIC50:  12nMAssay Description:Inhibition of GABAA alpha2 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50608947(CHEMBL5281056)
Affinity DataIC50:  24nMAssay Description:Inhibition of GABAA alpha2 receptor (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337271(2-(4-chlorophenyl)-3-(4-fluorobenzyloxy)-6,7,8,9-t...)
Affinity DataIC50:  57nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337270(2-(4-chlorophenyl)-3-(2-fluorobenzyloxy)-6,7,8,9-t...)
Affinity DataIC50:  154nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337264(2-(benzo[d][1,3]dioxol-5-yl)-3-(2-chlorobenzyloxy)...)
Affinity DataIC50:  155nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337269(3-(4-chlorobenzyloxy)-2-(4-chlorophenyl)-6,7,8,9-t...)
Affinity DataIC50:  177nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337275(2-(4-chlorophenyl)-3-(cyclopropylmethoxy)-6,7,8,9-...)
Affinity DataIC50:  185nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337268(3-(2-chlorobenzyloxy)-2-(4-chlorophenyl)-8,8-dimet...)
Affinity DataIC50:  213nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337274(3-(2-chlorobenzyloxy)-2-(4-chlorophenyl)-2H-pyrazo...)
Affinity DataIC50:  265nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337265(3-(2-chlorobenzyloxy)-2-(4-chlorophenyl)-6,7,8,9-t...)
Affinity DataIC50:  271nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588336(CHEMBL5186739)
Affinity DataIC50:  324nMAssay Description:Antagonist activity at human alpha2beta2gamma2 GABAA receptor expressed in HEK cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337267(3-(2-chlorobenzyloxy)-2-(4-chlorophenyl)-2,6,7,9-t...)
Affinity DataIC50:  461nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337272(2-(4-chlorophenyl)-3-(cyclopropylmethoxy)-2H-pyraz...)
Affinity DataIC50:  472nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337266(3-(2-chlorobenzyloxy)-2-(4-chlorophenyl)-2,6,7,8,9...)
Affinity DataIC50:  605nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50329649(1-phenylethyl 9H-pyrido[3,4-b]indole-3-carboxylate...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human recombinant GABAA alpha2 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337277(2-(4-chlorophenyl)-3-(cyclopropylmethoxy)-8-(1H-im...)
Affinity DataIC50:  2.11E+3nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588337(CHEMBL5177970)
Affinity DataIC50:  2.95E+3nMAssay Description:Antagonist activity at human alpha2beta2gamma2 GABAA receptor expressed in HEK cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50337276(3-(2-chlorophenoxy)-2-(4-chlorophenyl)-6,7,8,9-tet...)
Affinity DataIC50: >3.00E+3nMAssay Description:Displacement of [3H]flumazenil from GABAA receptor subunit alpha-2 expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588339(CHEMBL5187612)
Affinity DataIC50:  7.41E+3nMAssay Description:Antagonist activity at human alpha2beta2gamma2 GABAA receptor expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50580362(CHEMBL5086854)
Affinity DataIC50:  1.57E+4nMAssay Description:Negative allosteric modulation activity at human GABAA alpha2beta3gamma2 stably expressed in HEK cells by whole cell patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50588340(CHEMBL5204910)
Affinity DataIC50:  2.51E+4nMAssay Description:Antagonist activity at human alpha2beta2gamma2 GABAA receptor expressed in HEK293 cells by FMP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50454541(CHEMBL4210493)
Affinity DataIC50:  1.90E+5nMAssay Description:Inhibition of recombinant human GABA A alpha2beta2gamma2 receptor expressed in CHO-K1 cells incubated at room temperature for 15 mins before the GABA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50454543(CHEMBL4217850)
Affinity DataIC50:  8.90E+5nMAssay Description:Inhibition of recombinant human GABA A alpha2beta2gamma2 receptor expressed in CHO-K1 cells incubated at room temperature for 15 mins before the GABA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50454540(CHEMBL4213450)
Affinity DataIC50:  1.34E+6nMAssay Description:Inhibition of recombinant human GABA A alpha2beta2gamma2 receptor expressed in CHO-K1 cells incubated at room temperature for 15 mins before the GABA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50454542(CHEMBL4206129)
Affinity DataIC50: >2.40E+6nMAssay Description:Inhibition of recombinant human GABA A alpha2beta2gamma2 receptor expressed in CHO-K1 cells incubated at room temperature for 15 mins before the GABA...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed