Compile Data Set for Download or QSAR
maximum 50k data
Found 256 of ki for UniProtKB: P35228
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50386178(CHEMBL1800346 | ONO-1714)
Affinity DataKi:  1.80nMAssay Description:Inhibition of human iNOSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50386178(CHEMBL1800346 | ONO-1714)
Affinity DataKi:  1.86nMAssay Description:Inhibition of human iNOS assessed as inhibition of [3H]L-arginine to [3H]L-citrulline conversion by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50111438(3-{[(Benzo[1,3]dioxol-5-ylmethyl)-carbamoyl]-methy...)
Affinity DataKi:  2.20nMAssay Description:Binding against the partially purified human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065823(CHEMBL555794 | N-(3-Aminomethyl-phenyl)-2-methylsu...)
Affinity DataKi:  21nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50064015(7-Propyl-azepan-(2Z)-ylideneamine; hydrochloride |...)
Affinity DataKi:  90nMAssay Description:Inhibitory activity against L-arginine binding to Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065843(CHEMBL553081 | CHEMBL555715 | N-(3-Aminomethyl-phe...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065805(CHEMBL544788 | N-(3-Aminomethyl-benzyl)-acetamidin...)
Affinity DataKi:  140nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065807(CHEMBL552825 | N-(3-Aminomethyl-phenyl)-furan-2-ca...)
Affinity DataKi:  160nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

Curated by ChEMBL
LigandPNGBDBM50136951((4R,5R)-4-Methyl-5-pentyl-pyrrolidin-(2E)-ylidenea...)
Affinity DataKi:  250nMAssay Description:Inhibitory activity against Inducible nitric oxide synthaseChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50330882(CHEMBL1277951 | CHEMBL594682 | N1-((3R,4R)-4-((6-a...)
Affinity DataKi:  273nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50072297((S)-5-Acetimidoylamino-2-amino-pent | (S)-5-Acetim...)
Affinity DataKi:  340nMAssay Description:Inhibitory constant for the inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065813(CHEMBL555584 | N-(3-Aminomethyl-phenyl)-2-fluoro-a...)
Affinity DataKi:  480nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50330882(CHEMBL1277951 | CHEMBL594682 | N1-((3R,4R)-4-((6-a...)
Affinity DataKi:  581nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50289681(2-Amino-3-[2-(N'-methyl-guanidino)-phenyl]-propion...)
Affinity DataKi:  600nMAssay Description:Inhibitory constant for the inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50592473(CHEMBL5191295)
Affinity DataKi:  669nMAssay Description:Inhibition of human iNOS using L-arginine as substrate assessed as reduction in NO production in the presence of NADPH by NO-hemoglobin capture assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50225106((2S)-2-amino-5-{[(E)-amino(nitroimino)methyl]amino...)
Affinity DataKi:  670nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50341684(6,6'-(2,2'-(1,3-Phenylene)bis(ethane-2,1-diyl))bis...)
Affinity DataKi:  682nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM275051(US9878996, Compound 7)
Affinity DataKi:  770nMAssay Description:Assays were performed at the NIMH Psychoactive Drug Screening Program (PDSP) at UNC-Chapel Hill.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50230993((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...)
Affinity DataKi:  860nMAssay Description:Inhibitory constant for the inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50230993((2S)-2-amino-5-[(N-methylcarbamimidoyl)amino]penta...)
Affinity DataKi:  860nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50058459(2-Ethyl-1-phenyl-isothiourea; hydriodide | CHEMBL4...)
Affinity DataKi:  870nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM275050(US9878996, Compound 6)
Affinity DataKi:  1.10E+3nMAssay Description:Assays were performed at the NIMH Psychoactive Drug Screening Program (PDSP) at UNC-Chapel Hill.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50526363(CHEMBL4440481)
Affinity DataKi:  1.31E+3nMAssay Description:Inhibition of human iNOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemoglobin NO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50058448(2-Ethyl-1-(2-methoxy-phenyl)-isothiourea; hydrochl...)
Affinity DataKi:  1.40E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50341682(6,6'-(2,2'-(Pyridine-3,5-diyl)bis(ethane-2,1-diyl)...)
Affinity DataKi:  1.45E+3nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50341682(6,6'-(2,2'-(Pyridine-3,5-diyl)bis(ethane-2,1-diyl)...)
Affinity DataKi:  1.45E+3nMAssay Description:Inhibition assay using nitric oxide synthases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065842(CHEMBL540048 | N-(4-{[3-(1-Imino-ethyl)-benzylamin...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50526359(CHEMBL4450896)
Affinity DataKi:  1.64E+3nMAssay Description:Inhibition of human iNOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemoglobin NO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50526373(CHEMBL4590333)
Affinity DataKi:  1.78E+3nMAssay Description:Inhibition of human iNOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemoglobin NO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM275056(US9878996, Compound 29)
Affinity DataKi:  1.80E+3nMAssay Description:Assays were performed at the NIMH Psychoactive Drug Screening Program (PDSP) at UNC-Chapel Hill.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50441007(CHEMBL2430149 | US9732037, Compound 19)
Affinity DataKi:  1.86E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50014713(CHEMBL3262022 | US10759791, Compound 6 | US9951014...)
Affinity DataKi:  1.89E+3nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50058443(2-Ethyl-1-p-tolyl-isothiourea; hydrochloride | CHE...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM275053(US9878996, Compound 26)
Affinity DataKi:  1.90E+3nMAssay Description:Assays were performed at the NIMH Psychoactive Drug Screening Program (PDSP) at UNC-Chapel Hill.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50289677(3-(2-Acetimidoylamino-phenyl)-2-amino-propionic ac...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibitory constant for the inhibition of human Inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50446249(CHEMBL3109189 | US9732037, Compound 8)
Affinity DataKi:  1.90E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50341681(4-(2-(5-(2-(6-Amino-4-methylpyridin-2-yl)ethyl)pyr...)
Affinity DataKi:  1.91E+3nMAssay Description:Inhibition assay using nitric oxide synthases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065841(CHEMBL545025 | N-[4-(Acetimidoylamino-methyl)-phen...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM275052(US9878996, Compound 25)
Affinity DataKi:  2.00E+3nMAssay Description:Assays were performed at the NIMH Psychoactive Drug Screening Program (PDSP) at UNC-Chapel Hill.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065833(CHEMBL542432 | N-(4-Aminomethyl-phenyl)-acetamidin...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM344408(US9783500, Compound 10 | US9783500, Compound 4)
Affinity DataKi:  2.08E+3nMAssay Description:Rat and human nNOS, murine macrophage iNOS, and human eNOS were recombinant enzymes (expressed in E. coli and purified as reported previously in the ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM152712(4-methyl-6-[2-(5-{methyl[2-(methylamino)ethyl]amin...)
Affinity DataKi:  2.15E+3nMAssay Description:The NOSs isoform assays involved subjecting 3-8 to an oxyhemoglobin NO capture assay using a Biotek Gen5™ microplate reader. IC50 values for each com...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50374677(CHEMBL405231)
Affinity DataKi:  2.20E+3nMAssay Description:Inhibition of full length iNOS by high-throughput oxymyoglobin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50526361(CHEMBL4532683)
Affinity DataKi:  2.22E+3nMAssay Description:Inhibition of human iNOS expressed in Escherichia coli using L-arginine as substrate in presence of human oxyhemoglobin after 6 mins by hemoglobin NO...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50441008(CHEMBL2430150 | US9732037, Compound 20)
Affinity DataKi:  2.26E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50446252(CHEMBL3109186 | US9732037, Compound 6)
Affinity DataKi:  2.27E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50446248(CHEMBL3109190 | US9732037, Compound 10)
Affinity DataKi:  2.32E+3nMAssay Description:NOS inhibition assays of representative compounds 1-21 were undertaken, and the results are summarized in Table 1, below. All NOS isoforms were expre...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50058455(1-(3-Chloro-phenyl)-2-ethyl-isothiourea; hydrochlo...)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50065828(CHEMBL542678 | N-(3-Aminomethyl-phenyl)-acetamidin...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS) isoenzyme.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNitric oxide synthase, inducible(Homo sapiens (Human))
Instituto Cajal (Csic)

Curated by ChEMBL
LigandPNGBDBM50058444(2-Ethyl-1-(4-hydroxy-phenyl)-isothiourea; hydriodi...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibitory activity against human inducible nitric oxide synthase (iNOS).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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