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Found 1196 of ic50 for UniProtKB: P48775
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50606773(CHEMBL5220107)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of TDO in human BT-549 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556074(CHEMBL4787695)
Affinity DataIC50:  4nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556074(CHEMBL4787695)
Affinity DataIC50:  4nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50590774(CHEMBL5203175)
Affinity DataIC50:  9.60nMAssay Description:Inhibition of human TDOMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556077(CHEMBL4765090)
Affinity DataIC50:  10nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM541856(US11267824, Example 68a)
Affinity DataIC50:  11.6nMAssay Description:TDO2: Recombinant human TDO comprising amino acids 19-407 with a N-terminal hexahistidine tag expressed in E. coli and purified to homogeneity is inc...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556061(CHEMBL4756155)
Affinity DataIC50:  14nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556061(CHEMBL4756155)
Affinity DataIC50:  14nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556065(CHEMBL4747779)
Affinity DataIC50:  15nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556047(CHEMBL4780314)
Affinity DataIC50:  15nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM541934(US11267824, Example 140a)
Affinity DataIC50:  15.8nMAssay Description:TDO2: Recombinant human TDO comprising amino acids 19-407 with a N-terminal hexahistidine tag expressed in E. coli and purified to homogeneity is inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556066(CHEMBL4791729)
Affinity DataIC50:  18nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556063(CHEMBL4753714)
Affinity DataIC50:  18nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM541933(US11267824, Example 140)
Affinity DataIC50:  19.9nMAssay Description:TDO2: Recombinant human TDO comprising amino acids 19-407 with a N-terminal hexahistidine tag expressed in E. coli and purified to homogeneity is inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50511732(CHEMBL4434743)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human TDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50567017(CHEMBL4862796)
Affinity DataIC50:  20nMAssay Description:Inhibition of human TDO2 expressed in mouse P815B cells assessed as kynurenine concentration formation using L-tryptophan as substrate incubated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM541886(US11267824, Example 96 | US11267824, Example 96a)
Affinity DataIC50:  20nMAssay Description:TDO2: Recombinant human TDO comprising amino acids 19-407 with a N-terminal hexahistidine tag expressed in E. coli and purified to homogeneity is inc...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM370419(2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol | US1023...)
Affinity DataIC50:  20nMAssay Description:Inhibition of recombinant human TDO using L-tryptophan as substrate preincubated for 5 mins followed by substrate addition and measured after 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556070(CHEMBL4798028)
Affinity DataIC50:  21nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM541834(US11267824, Example 52)
Affinity DataIC50:  22.3nMAssay Description:TDO2: Recombinant human TDO comprising amino acids 19-407 with a N-terminal hexahistidine tag expressed in E. coli and purified to homogeneity is inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50550890(CHEMBL4747079)
Affinity DataIC50:  25nMAssay Description:Inhibition of recombinant human TDO assessed as reduction in kynurenine formation using L-tryptophan as substrate incubated for 45 mins by microplate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556060(CHEMBL4783665)
Affinity DataIC50:  25nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556062(CHEMBL4785841)
Affinity DataIC50:  25nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50541645(CHEMBL4642346)
Affinity DataIC50:  25nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50205741(CHEMBL3947656)
Affinity DataIC50:  26nMAssay Description:Inhibition of TDO2 in human A172 cells assessed as kynurenine formation after overnight incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50205695(CHEMBL3941937)
Affinity DataIC50:  27nMAssay Description:Inhibition of TDO2 in human A172 cells assessed as kynurenine formation after overnight incubationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50321325(CHEMBL4173485)
Affinity DataIC50:  28nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556054(CHEMBL4777219)
Affinity DataIC50:  28nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM541966(US11267824, Example 172)
Affinity DataIC50:  28.7nMAssay Description:TDO2: Recombinant human TDO comprising amino acids 19-407 with a N-terminal hexahistidine tag expressed in E. coli and purified to homogeneity is inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50590774(CHEMBL5203175)
Affinity DataIC50:  29nMAssay Description:Inhibition of human TDOMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50321332(CHEMBL4165554)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant human TDO2 assessed as decrease in conversion of L-tryptophan to N-formylkynurenine preincubated for 5 mins followed by 0.2...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50606771(CHEMBL5218853)
Affinity DataIC50:  29nMAssay Description:Inhibition of recombinant C-terminal His tagged TDO (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM541855(US11267824, Example 68)
Affinity DataIC50:  29.3nMAssay Description:TDO2: Recombinant human TDO comprising amino acids 19-407 with a N-terminal hexahistidine tag expressed in E. coli and purified to homogeneity is inc...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50126144(CHEMBL3629569 | US10155972, Compound NewLink 1 | U...)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human TDO2 expressed in Escherichia coli BL21 (DE3) assessed as reduction in N-formylkynurenine formation using L-tryptopha...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50127174(CHEMBL3628599)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli incubated for 1 hr measured by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50542388(CHEMBL4645973)
Affinity DataIC50:  30nMAssay Description:Inhibition of recombinant human TDO expressed in Escherichia coli BL21 using L-Trp as substrate incubated for 30 mins by enzymatic assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50127174(CHEMBL3628599)
Affinity DataIC50:  30nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50127204(CHEMBL3628602)
Affinity DataIC50:  30nMAssay Description:Inhibition of TDO (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50515069(CHEMBL4522927 | US10899764, Example 28)
Affinity DataIC50:  30.6nMAssay Description:TDO: For testing, 24 μL of enzyme (TDO) was diluted 100 times with 50 mM KPB to 2400 μL. The concentration of the enzyme solution was 2.6 n...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556069(CHEMBL4763934)
Affinity DataIC50:  34nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556064(CHEMBL4753565)
Affinity DataIC50:  34nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556046(CHEMBL4749726)
Affinity DataIC50:  36nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50127174(CHEMBL3628599)
Affinity DataIC50:  36nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM541968(US11267824, Example 174)
Affinity DataIC50:  37.9nMAssay Description:TDO2: Recombinant human TDO comprising amino acids 19-407 with a N-terminal hexahistidine tag expressed in E. coli and purified to homogeneity is inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM541886(US11267824, Example 96 | US11267824, Example 96a)
Affinity DataIC50:  39.9nMAssay Description:TDO2: Recombinant human TDO comprising amino acids 19-407 with a N-terminal hexahistidine tag expressed in E. coli and purified to homogeneity is inc...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50442991(CHEMBL432537 | GNF-Pf-3777 | US10669273, Compound ...)
Affinity DataIC50:  40nMAssay Description:Inhibition of TDO in human U87 MG cells using L-Trp as substrate after 8 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50606613(CHEMBL5219865)
Affinity DataIC50:  40nMAssay Description:Inhibition of human TDO (19 to 388 aa) expressed in Escherichia coli Transetta (DE3) by nanodrop 2000c spectrophotometric analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM480515(US10899764, Example 41)
Affinity DataIC50:  42nMAssay Description:TDO: For testing, 24 μL of enzyme (TDO) was diluted 100 times with 50 mM KPB to 2400 μL. The concentration of the enzyme solution was 2.6 n...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM50556068(CHEMBL4783159)
Affinity DataIC50:  42nMAssay Description:Inhibition of TDO (unknown origin) assessed as reduction in L-kynurenine formation using L-tryptophan as substrate incubated for 30 mins microplate s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTryptophan 2,3-dioxygenase(Homo sapiens (Human))
National Clinical Research Center For Geriatrics

Curated by ChEMBL
LigandPNGBDBM541850(US11267824, Example 48a)
Affinity DataIC50:  42.5nMAssay Description:TDO2: Recombinant human TDO comprising amino acids 19-407 with a N-terminal hexahistidine tag expressed in E. coli and purified to homogeneity is inc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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