Compile Data Set for Download or QSAR
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Found 82 of ic50 for UniProtKB: P31648
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50426075(CHEMBL473104)
Affinity DataIC50:  40nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50426072(CHEMBL1190520)
Affinity DataIC50:  55nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50039251((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...)
Affinity DataIC50:  63.1nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50426074(CHEMBL2315957)
Affinity DataIC50:  80nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50368628(ABT-569 | Abbott-70569 | Abbott-70569.1 | Gabitril...)
Affinity DataIC50:  80nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50426073(CHEMBL2315958)
Affinity DataIC50:  100nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50003634(1-(4,4-Diphenyl-but-3-enyl)-piperidine-3-carboxyli...)
Affinity DataIC50:  130nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50039251((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...)
Affinity DataIC50:  191nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304268((S)-2-(1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl...)
Affinity DataIC50:  340nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304266((S)-2-(1-(4,4-diphenylbut-3-enyl)pyrrolidin-2-yl)a...)
Affinity DataIC50:  400nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304267((S)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)py...)
Affinity DataIC50:  650nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50039251((R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-enyl)pi...)
Affinity DataIC50:  800nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50371220(CHEMBL538839)
Affinity DataIC50:  920nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50371217(CHEMBL558578)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304265((S)-1-(4,4-diphenylbut-3-enyl)pyrrolidine-2-carbox...)
Affinity DataIC50:  2.56E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304263(2-((2S,4R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-...)
Affinity DataIC50:  2.97E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304271(2-((2S,4R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-...)
Affinity DataIC50:  3.15E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304270(2-((2S,4R)-1-(4,4-diphenylbut-3-enyl)-4-hydroxypyr...)
Affinity DataIC50:  3.29E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304261(2-((2S,4R)-1-(4,4-diphenylbut-3-enyl)-4-fluoropyrr...)
Affinity DataIC50:  3.96E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50343258(4-((4,4-bis(3-methylthiophen-2-yl)but-3-enyl)(meth...)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304272(2-((2S,4S)-1-(4,4-diphenylbut-3-enyl)-4-hydroxypyr...)
Affinity DataIC50:  4.92E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304264(2-((2S,4S)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-...)
Affinity DataIC50:  4.94E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304273(2-((2S,4S)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-...)
Affinity DataIC50:  5.14E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304262(2-((2S,4S)-1-(4,4-diphenylbut-3-enyl)-4-fluoropyrr...)
Affinity DataIC50:  5.81E+3nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50343258(4-((4,4-bis(3-methylthiophen-2-yl)but-3-enyl)(meth...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM24183(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Affinity DataIC50:  7.24E+3nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50003624((RS)-nipecotic acid | CHEMBL277498 | Nipecotic | P...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50426076(CHEMBL2315983)
Affinity DataIC50:  1.00E+4nMAssay Description:Binding affinity to mouse GAT1 expressed in HEK293 cells membranes using LC-ESI-MS/MS analysis by [2H10]NO711 binding inhibition assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50:  1.02E+4nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50213498((R)-1-(3-(benzhydrylthio)propyl)piperidine-3-carbo...)
Affinity DataIC50:  1.16E+4nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM90787(1,2,3,6-tetrahydropyridine-5-carboxylic acid;hydro...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 25 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304276((2S,4R)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-eny...)
Affinity DataIC50:  1.28E+4nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50213501((R)-1-(3-(dip-tolylmethylthio)propyl)piperidine-3-...)
Affinity DataIC50:  1.58E+4nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50213497((3R)-1-(3-((2,3-dimethylphenyl)(o-tolyl)methylthio...)
Affinity DataIC50:  1.69E+4nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304260((2S,4S)-1-(4,4-bis(3-methylthiophen-2-yl)but-3-eny...)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50320523(1-(3-(9H-carbazol-9-yl)propyl)-4-(4-methoxyphenyl)...)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50419338(CHEMBL1446457)
Affinity DataIC50:  1.91E+4nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in BHK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304274((2S,4R)-1-(4,4-diphenyl-3-butenyl)-4-fluoropyrroli...)
Affinity DataIC50:  6.74E+4nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50026409(5-Amino-Pentanoic Acid | 5-Aminopentanoic Acid | 5...)
Affinity DataIC50:  7.41E+4nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304269((2S,4R)-1-(4,4-diphenylbut-3-enyl)-4-hydroxypyrrol...)
Affinity DataIC50:  7.96E+4nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50039246((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...)
Affinity DataIC50:  8.50E+4nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50304275((2S,4S)-1-(4,4-Diphenyl-but-3-enyl)-4-fluoro-pyrro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of GAT1 in mouse D8 cells assessed as [3H]GABA transport by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50371219(CHEMBL536762)
Affinity DataIC50:  1.05E+5nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM84684(1-Subsituted 1H-imidazole, 21 | CHEMBL543494)
Affinity DataIC50:  1.15E+5nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50026418(CHEMBL1773947)
Affinity DataIC50:  1.17E+5nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50213503((R)-1-(3-(bis(4-methoxyphenyl)methylthio)propyl)pi...)
Affinity DataIC50:  1.20E+5nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50026417(CHEMBL1773946)
Affinity DataIC50:  1.23E+5nMAssay Description:Inhibition of mouse GAT1-mediated [3H]GABA uptake expressed in human HEK cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50213502((R)-1-(2-(dip-tolylmethylthio)ethyl)piperidine-3-c...)
Affinity DataIC50:  2.40E+5nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in D8 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Mus musculus)
Ludwig Maximilians University At Munich

Curated by ChEMBL
LigandPNGBDBM50427390(CHEMBL2326022)
Affinity DataIC50: >3.00E+5nMAssay Description:Inhibition of [3H]GABA uptake at mouse GAT1 expressed in HEK293 cells after 3 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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