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Found 97 of ic50 for UniProtKB: P28347
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626350(2-[[[4-cyano-7-(4-isopropyl-2- thienyl)-2,3-dihyd...)
Affinity DataIC50:  10nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626350(2-[[[4-cyano-7-(4-isopropyl-2- thienyl)-2,3-dihyd...)
Affinity DataIC50:  10nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626318(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataIC50:  20nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626331(US11787775, Compound 16-C)
Affinity DataIC50:  20nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626318(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataIC50:  20nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626318(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataIC50:  20nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM50271260(CHEMBL4130196)
Affinity DataIC50:  25nMAssay Description:Inhibition of human His-tagged YAP (50 to 171 residues) interaction with human GST-tagged TEAD1 (194 to 411) expressed in Escherichia coli BL21(DE3) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM50497300(CHEMBL3335461)
Affinity DataIC50:  25nMAssay Description:Inhibition of YAP/ GST-TEAD1 (unknown origin) interaction by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626361(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50:  30nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626361(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50:  30nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626333(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  30nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50:  40nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM50497290(CHEMBL3335458)
Affinity DataIC50:  41nMAssay Description:Inhibition of YAP/ GST-TEAD1 (unknown origin) interaction by surface plasmon resonance assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM50497304(CHEMBL3335453)
Affinity DataIC50:  42nMAssay Description:Inhibition of YAP/ GST-TEAD1 (unknown origin) interaction by surface plasmon resonance assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626362(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50:  50nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626342(2-[[[4-cyano-7-(2-fluoro-4- isopropyl-phenyl)-2,3...)
Affinity DataIC50:  50nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626334(2-[[[4-cyano-7-[4-(1,1- difluoroethyl)phenyl]-2,3...)
Affinity DataIC50:  50nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50:  50nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626362(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50:  50nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626330(2-[[[4-cyano-7-[4- (trifluoromethyl)phenyl]-2,3- ...)
Affinity DataIC50:  50nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626336(2-[[[4-fluoro-7-(4-isopropylphenyl)- 2,3-dihydrob...)
Affinity DataIC50:  60nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626324(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataIC50:  60nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50:  60nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626324(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataIC50:  60nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626354(2-[[[4-cyano-2,2-dideuterio-7-[4- (trifluorometho...)
Affinity DataIC50:  70nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626323(US11787775, Compound 8 | methyl 2-[[[4-cyano-7-(4-...)
Affinity DataIC50:  70nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM50497306(CHEMBL3335463)
Affinity DataIC50:  75nMAssay Description:Inhibition of YAP/ GST-TEAD1 (unknown origin) interaction by surface plasmon resonance assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626332(US11787775, Compound 16-D)
Affinity DataIC50:  80nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626358(2-[[[7-cyano-4-[4- (trifluoromethoxy)phenyl]-1,3-...)
Affinity DataIC50:  80nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM50271259(CHEMBL4129172)
Affinity DataIC50:  83nMAssay Description:Inhibition of Gal4-fused TEAD 1 (unknown origin) interaction with YAP expressed in human 293T cells by Dual-Glo luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626355(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50:  90nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626337(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrofu...)
Affinity DataIC50:  90nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626355(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50:  100nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626360(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  110nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626358(2-[[[7-cyano-4-[4- (trifluoromethoxy)phenyl]-1,3-...)
Affinity DataIC50:  140nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM50497296(CHEMBL3335452)
Affinity DataIC50:  150nMAssay Description:Inhibition of YAP/ GST-TEAD1 (unknown origin) interaction by surface plasmon resonance assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626338(2-[[[7-cyano-4-[4-(1,1- difluoroethyl)phenyl]-1,3...)
Affinity DataIC50:  160nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626352(2-[[[4-(hydroxymethyl)-7-[4- (trifluoromethoxy)ph...)
Affinity DataIC50:  160nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626326(7-(4-isopropylphenyl)-5-[(2- methylene-3-oxo-buty...)
Affinity DataIC50:  180nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626319(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataIC50:  180nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626365(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50:  200nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626335(2-[[[4-(4-isopropylphenyl)-6,7- dihydrofuro[3,2-d...)
Affinity DataIC50:  200nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626365(2-[[[7-cyano-4-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50:  210nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626319(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataIC50:  220nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626316(2-[[[7-(4-isopropylphenyl)-2,3- dihydrobenzofuran...)
Affinity DataIC50:  220nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626360(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  240nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626363(2-[[[4-cyano-7-[4-(pentafluoro- lambda6-sulfanyl)...)
Affinity DataIC50:  250nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626359(2-[[[4-cyano-7-[4- (trifluoromethoxy)phenyl]-2,3-...)
Affinity DataIC50:  280nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTranscriptional enhancer factor TEF-1(Homo sapiens)
Genentech

US Patent
LigandPNGBDBM626324(2-[[[4-cyano-7-(4-isopropylphenyl)- 2,3-dihydrobe...)
Affinity DataIC50:  280nMAssay Description:Table 2-3: His-tagged TEAD proteins are pre-incubated with TEAD project compounds for 30 minutes or 4 hours at room temperature. Biotinylated lipid p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM626364(2-[[[4-cyano-7-(5-isopropylthiazol- 2-yl)-2,3-dih...)
Affinity DataIC50:  300nMAssay Description:Table 4-5: Purified His-tagged TEAD protein (YAP Binding Domain, amino acids 217-447) is pre-incubated with Europium labelled anti-His antibody trace...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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