Compile Data Set for Download or QSAR
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Found 305 of ic50 for UniProtKB: P14679
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM7459(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  0.613nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50241367(2-(3,4-Dihydroxy-phenyl)-5,7-dihydroxy-3-((2S,4R,5...)
Affinity DataIC50:  0.762nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50217942(2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chr...)
Affinity DataIC50:  0.856nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50378581(NICOTIFLOROSIDE)
Affinity DataIC50:  0.908nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human his tagged tyrosinase expressed in HEK293 cells using L-DOPA as substrate by HTS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50269559(2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4...)
Affinity DataIC50:  23nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-dihydroxyphenylalanine as substrate preincubated for 30 mins followed by substrate addition measure...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50287127((S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbony...)
Affinity DataIC50:  60nMAssay Description:Compound was evaluated for inhibition of tyrosinase enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50203985((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...)
Affinity DataIC50:  70nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50203985((E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl...)
Affinity DataIC50:  70nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50251013(2,4,2',4'-tetrahydroxy-3'-prenylchalcone | CHEMBL4...)
Affinity DataIC50:  80nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50251013(2,4,2',4'-tetrahydroxy-3'-prenylchalcone | CHEMBL4...)
Affinity DataIC50:  80nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50031467(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Affinity DataIC50:  80nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50108046((oxyresveratrol)4-[(E)-2-(3,5-dihydroxyphenyl)viny...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human tyrosinase expressed in HEK293 cells using L-tyrosine and DOPA as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50441626(GLABRIDIN | US9783551, Compound 1)
Affinity DataIC50:  90nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate preincubated for 5 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50172095(CHEBI:69084 | Glyasperin D)
Affinity DataIC50:  154nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate assessed as oxidation of L-tyrosine after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50529589(CHEMBL4239110)
Affinity DataIC50:  170nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50529589(CHEMBL4239110)
Affinity DataIC50:  170nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50172096(CHEBI:69089 | Glyasperin C)
Affinity DataIC50:  177nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate assessed as oxidation of L-tyrosine after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50146416((S)-2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Affinity DataIC50:  240nMAssay Description:Inhibitory activity against mushroom tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM85807(Beta-PEA | CAS_60-12-8 | NSC_6054)
Affinity DataIC50:  315nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50146418((S)-2-{(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Affinity DataIC50:  330nMAssay Description:Inhibitory activity against mushroom tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50263336(4,4'-(ethane-1,2-diyl)dibenzene-1,3-diol | CHEMBL4...)
Affinity DataIC50:  370nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50146415((S)-2-[(S)-2-[(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-yl...)
Affinity DataIC50:  390nMAssay Description:Inhibitory activity against mushroom tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50264086((2S,3R,4S,5R)-2-(4-(2,4-dihydroxyphenethyl)-3-hydr...)
Affinity DataIC50:  430nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50292636(4-hexyl resorcinol | ACRISORCIN | CHEMBL443605)
Affinity DataIC50:  560nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50608337((+)-Anymol | CHEMBL477832)
Affinity DataIC50:  635nMAssay Description:Inhibition of tyrosinase (unknown origin) using DOPA as substrate incubated for 15 min by spectrophotometer assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50340788(4-(beta-D-Cellobiopyranosyl)-2,2',4'-trihydroxybib...)
Affinity DataIC50:  680nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50366430(CHEMBL1794031)
Affinity DataIC50:  700nMAssay Description:Compound was evaluated for inhibition of tyrosinase enzyme.More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50264087((2S,2'S,3R,3'R,4S,4'S,5R,5'R)-2,2'-(4-(2,4-dihydro...)
Affinity DataIC50:  730nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50340787(4-(beta-D-Glucopyranosyl)-2,2',4'-trihydroxybibenz...)
Affinity DataIC50:  770nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50146414((2S)-2-[(2S)-2-[(2S)-2-({[(5-hydroxy-4-oxo-4H-pyra...)
Affinity DataIC50:  780nMAssay Description:Inhibitory activity against mushroom tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50340789(2,2',4'-Trihydroxy-4-(beta-D-maltopyranosyl)bibenz...)
Affinity DataIC50:  830nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50251005((2S)-5,7,2',4'-tetrahydroxyflavanone | (S)-2-(2,4-...)
Affinity DataIC50:  980nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50251005((2S)-5,7,2',4'-tetrahydroxyflavanone | (S)-2-(2,4-...)
Affinity DataIC50:  980nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50559078(SUBAMOLIDE A)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of tyrosinase in human neonatal foreskin epidermal melanocyte cells using L-tyrosine and L-DOPA as substrate preincubated for 2 days follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50559077(CHEMBL4473314)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of tyrosinase in human neonatal foreskin epidermal melanocyte cells using L-tyrosine and L-DOPA as substrate preincubated for 2 days follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM7462(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-tyrosine as substrate assessed as oxidation of L-tyrosine after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50540075(CHEMBL2078992)
Affinity DataIC50:  1.07E+3nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50559076(CHEMBL4743159)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human His-tagged tyrosinase expressed in HEK 293 cells using L-DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50330795(2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one ...)
Affinity DataIC50:  1.15E+3nMAssay Description:Competitive inhibition of tyrosinase in human G-361 cells incubated for 10 mins measured for 2 hrs by MBTH-based spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50330795(2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one ...)
Affinity DataIC50:  1.15E+3nMAssay Description:Inhibition of human tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50330795(2-hydroxy-5-isopropyl-2,4,6-cycloheptatrien-1-one ...)
Affinity DataIC50:  1.15E+3nMAssay Description:Inhibition of human tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50559093(CHEMBL4763438)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50205807(CHEMBL3978212)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of tyrosinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50120802(CHEMBL3100130)
Affinity DataIC50:  1.51E+3nMAssay Description:Inhibition of tyrosinase (unknown origin) using L-DOPA as substrate assessed as formation of dopachrome by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50219502(4-hydroxyphenyl beta-D-glucopyranoside | Arbutin |...)
Affinity DataIC50: >1.60E+3nMAssay Description:Inhibition of tyrosinase (unknown origin) assessed as reduction in melanin formationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50193667(2,4,3',5'-tetrahydroxybibenzyl | CHEMBL221291)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of tyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50559091(CHEMBL4792744)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of human tyrosinase using L- DOPA as substrate by MBTH based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosinase(Homo sapiens (Human))TBA
LigandPNGBDBM50264085((2S,3R,4S,5R)-2-(2-(2,4-dihydroxyphenethyl)-5-hydr...)
Affinity DataIC50:  1.60E+3nMAssay Description:Inhibition of TyrosinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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