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Found 281 of ic50 for UniProtKB: P36544
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170589((3S)-3-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2...)
Affinity DataIC50:  0.300nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170586((3S)-3-{[(2S)-1-[(2S)-2-[(2S,3R)-2-[(2S)-2-[(2S)-2...)
Affinity DataIC50:  0.75nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha7; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50393253(CHEMBL2151573)
Affinity DataIC50:  1.09nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus oocyteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50140089(CHEMBL437423 | GCCSHPACAGNNQHIC*)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50597513(CHEMBL5178473)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50597512(CHEMBL5201239)
Affinity DataIC50:  1.5nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170592(CHEMBL411146)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha7; Range is 0.3-1.5 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM80642(CHEMBL191491 | MG 624 | MLS002172460 | SMR00125409...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treate...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50597506(CHEMBL5190813)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50597507(CHEMBL5176101)
Affinity DataIC50:  2.30nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50597505(CHEMBL5174508)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50597504(CHEMBL5177606)
Affinity DataIC50:  2.80nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170584(CHEMBL411145)
Affinity DataIC50:  5nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha-7 Range is 3-5 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50175606(CHEMBL3302240)
Affinity DataIC50:  6nMAssay Description:Agonist activity at alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50466614(CHEMBL4291079)
Affinity DataIC50:  6.5nMAssay Description:Antagonist activity at human alpha7 nACHR expressed in xenopous laevis oocyte assessed as inhibition of ACh-induced channel current after 5 mins at -...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50140087(CHEMBL265198 | GCCSNPVCHLEHSNLC*)
Affinity DataIC50:  8nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha7; Range is 0.5-8 nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50366779(METHYLLYCACONITINE)
Affinity DataIC50:  8.30nMAssay Description:Antagonist activity at human alpha-7 nAChR in tsA201 cells coexpressed with Ric3 by FMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50366779(METHYLLYCACONITINE)
Affinity DataIC50:  8.30nMAssay Description:Antagonist activity at human alpha7nAChR co-expressed with human Ric3 in tsA201 cells by FMP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50339937(1,1',1''-(5,5',5''-(benzene-1,3,5-triyl)tris(penta...)
Affinity DataIC50:  8.80nMAssay Description:Antagonist activity at alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170600((3S)-3-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(...)
Affinity DataIC50:  9.60nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50175589(CHEMBL3302229)
Affinity DataIC50:  11nMAssay Description:Agonist activity at alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50466607(CHEMBL4293646)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human alpha7 nACHR expressed in xenopous laevis oocyte assessed as inhibition of ACh-induced channel current after 5 mins at -...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50175603(CHEMBL3303977)
Affinity DataIC50:  19nMAssay Description:Agonist activity at alpha7 nAChR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50528722(CHEMBL4453847)
Affinity DataIC50:  21nMAssay Description:Induction of desensitization at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine induced current treate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50590141(CHEMBL5176133)
Affinity DataIC50:  23nMAssay Description:Negative allosteric modulation activity at alpha7 nAChR in human SH-SY5Y cells assessed as inhibition of choline induced intracellular calcium by FLI...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50466606(CHEMBL4280452)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human alpha7 nACHR expressed in xenopous laevis oocyte assessed as inhibition of ACh-induced channel current after 5 mins at -...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170588(CHEMBL451252)
Affinity DataIC50:  30nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50049757(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Affinity DataIC50:  31nMAssay Description:Inhibition of [3H]alpha-BGT binding to alpha7 nicotinic acetylcholine receptor in Homo sapiens (human) SH-SY5Y cellsMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM80642(CHEMBL191491 | MG 624 | MLS002172460 | SMR00125409...)
Affinity DataIC50:  41nMAssay Description:Antagonist activity at human alpha7 nACHR expressed in xenopous laevis oocyte assessed as inhibition of ACh-induced channel current after 5 mins at -...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50466613(CHEMBL4287656)
Affinity DataIC50:  47nMAssay Description:Antagonist activity at human alpha7 nACHR expressed in xenopous laevis oocyte assessed as inhibition of ACh-induced channel current after 5 mins at -...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50405810(CHEMBL5284610)
Affinity DataIC50:  60nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50170603((3S)-3-{[(2S)-1-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(...)
Affinity DataIC50:  61nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50514670(CHEMBL4555265)
Affinity DataIC50:  63nMAssay Description:Inhibition of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-evoked currents by two-electrode voltage clamp ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50405814(CHEMBL5285899)
Affinity DataIC50:  70nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50597510(CHEMBL5176690)
Affinity DataIC50:  78nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response treate...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50405806(CHEMBL5275653)
Affinity DataIC50:  80nMAssay Description:In vitro inhibitory activity against human Carbonic anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50587094(CHEMBL5083247)
Affinity DataIC50:  86nMAssay Description:Antagonist activity at human alpha7 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50405807(CHEMBL5287773)
Affinity DataIC50:  90nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50339936(2,2',2''-(5,5',5''-(benzene-1,3,5-triyl)tris(penta...)
Affinity DataIC50:  91nMAssay Description:Antagonist activity at alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50466608(CHEMBL4285772)
Affinity DataIC50:  92nMAssay Description:Antagonist activity at human alpha7 nACHR expressed in xenopous laevis oocyte assessed as inhibition of ACh-induced channel current after 5 mins at -...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50339938(1,1',1'',1'''-(5,5',5'',5'''-(benzene-1,2,4,5-tetr...)
Affinity DataIC50:  99nMAssay Description:Antagonist activity at alpha7 nAChR expressed in Xenopus oocyte assessed as inhibition of ACh-gated current by voltage clamp electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405803(CHEMBL5284469)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405805(CHEMBL5289840)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50445327(CHEMBL3104240)
Affinity DataIC50:  103nMAssay Description:Inhibition of alpha7 nAChR (unknown origin) expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50405802(CHEMBL5278951)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405801(CHEMBL5289950)
Affinity DataIC50:  110nMAssay Description:In vitro inhibitory concentration against rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM80642(CHEMBL191491 | MG 624 | MLS002172460 | SMR00125409...)
Affinity DataIC50:  110nMAssay Description:Inhibitory concentration against Nicotinic acetylcholine receptor alpha 7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
The Danish University Of Pharmaceutical Sciences

Curated by ChEMBL
LigandPNGBDBM50606633(CHEMBL5219936)
Affinity DataIC50:  115nMAssay Description:Inhibition of human alpha7 nAChR expressed in xenopus oocytes assessed as inhibition of Ach- induced response at -70 mV holding potential and measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
LigandPNGBDBM50405811(CHEMBL5277536)
Affinity DataIC50:  120nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50405808(CHEMBL5279096)
Affinity DataIC50:  130nMAssay Description:In vitro inhibition of human Carbonic Anhydrase IIMore data for this Ligand-Target Pair
In DepthDetails PubMed
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