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Found 27 of ki for UniProtKB: P20035
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM92358(HGXPRT Inhibitor, 3)
Affinity DataKi:  0.650nM ΔG°:  -13.0kcal/molepH: 7.6 T: 2°CAssay Description:PfHGXPRT activity was measured using spectrophotometric assay observing the conversion of xanthine and 5-phospho-alpha-D-ribose-1-pyrophosphate to xa...More data for this Ligand-Target Pair
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM92357(HGXPRT Inhibitor, 2)
Affinity DataKi:  10.6nM ΔG°:  -11.3kcal/molepH: 7.6 T: 2°CAssay Description:PfHGXPRT activity was measured using spectrophotometric assay observing the conversion of xanthine and 5-phospho-alpha-D-ribose-1-pyrophosphate to xa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194490(US9200020, Table 1, Compound 1)
Affinity DataKi:  100nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194500(US9200020, Table 3 compound 9)
Affinity DataKi:  100nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60887(US9200020, Table 3, Compound 2B)
Affinity DataKi:  100nM ΔG°:  -9.93kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194493(US9200020, Table 3 compound 2)
Affinity DataKi:  100nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194499(US9200020, Table 3 compound 8)
Affinity DataKi:  200nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194496(US9200020, Table 3 compound 5)
Affinity DataKi:  200nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194501(US9200020, Table 3 compound 10)
Affinity DataKi:  200nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60890(US9200020, Table 3 compound 5B)
Affinity DataKi:  200nM ΔG°:  -9.50kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60880(US9200020, Table 1, Compound 1B)
Affinity DataKi:  300nM ΔG°:  -9.25kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194502(US9200020, Table 3 compound 11)
Affinity DataKi:  300nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60893(US9200020, Table 3 compound 8B)
Affinity DataKi:  400nM ΔG°:  -9.07kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60897(US9200020, Table 3 compound 11B)
Affinity DataKi:  400nM ΔG°:  -9.07kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60892(US9200020, Table 3 compound 7B)
Affinity DataKi:  600nM ΔG°:  -8.82kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194498(US9200020, Table 3 compound 7)
Affinity DataKi:  700nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194494(US9200020, Table 3 compound 3)
Affinity DataKi:  1.30E+3nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194492(US9200020, Table 3 compound 1)
Affinity DataKi:  1.70E+3nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60886(US9200020, Table 3, Compound 1B)
Affinity DataKi:  1.90E+3nM ΔG°:  -8.11kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60896(US9200020, Table 3 compound 10B)
Affinity DataKi:  2.60E+3nM ΔG°:  -7.92kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194497(US9200020, Table 3 compound 6)
Affinity DataKi:  4.00E+3nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60891(US9200020, Table 3 compound 6B)
Affinity DataKi:  6.00E+3nM ΔG°:  -7.41kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194491(US9200020, Table 1, Compound 2)
Affinity DataKi:  1.60E+4nMpH: 7.4Assay Description:The Ki values were determined using a spectrophotometric assay at 25° C., 0.1 M Tris-HCl, 10 mM MgCl2, pH 7.4 (Keough, D. T.; Ng, A. L.; Winzor, D. J...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60884(US9200020, Table 1, Compound 2B)
Affinity DataKi: >2.00E+5nM ΔG°: >-5.25kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60894(US9200020, Table 3 compound 9B)
Affinity DataKi: >2.10E+5nM ΔG°: >-5.22kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM60888(US9200020, Table 3, Compound 3B)
Affinity DataKi: >2.20E+5nM ΔG°: >-5.19kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHypoxanthine-guanine-xanthine phosphoribosyltransferase(Plasmodium falciparum)
Albert Einstein College of Medicine

LigandPNGBDBM194495(US9200020, Table 3 compound 4)
Affinity DataKi: >2.50E+5nM ΔG°: >-5.11kcal/moleT: 2°CAssay Description:The [3H]-hypoxanthine growth inhibition assay (Desjardins et al., 1979 Antimicrobial Agents Chemother 16: 710-718) was used to evaluate the in vitr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent