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Found 10 of ic50 for UniProtKB: P29846
TargetGenome polyprotein [1658-1692](Hepatitis C virus)
Astex Pharmaceuticals

LigandPNGBDBM92629((3S)-3-{[(1R)-1-(4-chloro-2-fluoro-3-phenoxyphenyl...)
Affinity DataIC50:  100nM Kd:  62nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus)
Astex Pharmaceuticals

LigandPNGBDBM92628((1R)-1-(2,4-difluoro-3-phenoxyphenyl)propan-1-amin...)
Affinity DataIC50:  1.30E+3nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Taiwan))
National Taiwan University

LigandPNGBDBM29340(triphenylmethane derivative, 12)
Affinity DataIC50:  1.01E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Taiwan))
National Taiwan University

LigandPNGBDBM29331(triphenylmethane derivative, 3)
Affinity DataIC50:  1.26E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Taiwan))
National Taiwan University

LigandPNGBDBM29334(triphenylmethane derivative, 6)
Affinity DataIC50:  1.39E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus)
Astex Pharmaceuticals

LigandPNGBDBM92627((2,4-difluoro-3-phenoxyphenyl)methanamine, 3)
Affinity DataIC50:  2.00E+4nM Kd:  2.90E+4nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Taiwan))
National Taiwan University

LigandPNGBDBM29332(triphenylmethane derivative, 4)
Affinity DataIC50:  2.97E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Taiwan))
National Taiwan University

LigandPNGBDBM29329(BHT, 1)
Affinity DataIC50:  4.00E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate Taiwan))
National Taiwan University

LigandPNGBDBM29338(diphenol | diphenol derivative, 10)
Affinity DataIC50:  6.07E+4nMpH: 7.0 T: 2°CAssay Description:The enzyme was assayed the DNA helicase activity by using DNA substrate (annealed BHQ1-labeled release strand and FITC-labeled template strand) in th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein [1658-1692](Hepatitis C virus)
Astex Pharmaceuticals

LigandPNGBDBM50271275(1H-Indazol-7-amine | 1H-indazol-7-amine, 1 | CHEMB...)
Affinity DataIC50: >5.00E+6nMT: 2°CAssay Description:The protease activity of the full-length NS3-NS4a and the protease domain were measured using a FRET-based assay using a peptide substrate derived fr...More data for this Ligand-Target Pair