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Found 225 of ic50 for UniProtKB: P26663
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM203919(US9242988, 1)
Affinity DataIC50:  3nMpH: 7.3 T: 2°CAssay Description:To measure inhibition of the enzymatic activity of the HCV NS5B RNA-dependent RNA polymerase by the nucleoside triphosphate compounds of the present ...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails US Patent
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM35554(thiophene scaffold, 21)
Affinity DataIC50:  9nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50081634(CHEMBL3422106)
Affinity DataIC50:  10nMAssay Description:Inhibition of HCV genotype 1b BK NS5B expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30466(benzothiazine-containing analog, 4a)
Affinity DataIC50: <10nM EC50:  1.5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30544(5,6-Dihydro-1H-pyridin-2-one, 4ap)
Affinity DataIC50: <10nM EC50:  55nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30543(5,6-Dihydro-1H-pyridin-2-one, 4ao)
Affinity DataIC50: <10nM EC50:  45nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30542(5,6-Dihydro-1H-pyridin-2-one, 4an)
Affinity DataIC50: <10nM EC50:  34nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30541(5,6-Dihydro-1H-pyridin-2-one, 4am)
Affinity DataIC50: <10nM EC50:  160nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30538(5,6-Dihydro-1H-pyridin-2-one, 4aj)
Affinity DataIC50: <10nM EC50:  9nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30537(5,6-Dihydro-1H-pyridin-2-one, 4ai)
Affinity DataIC50: <10nM EC50:  32nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30452(Hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 3 | hexah...)
Affinity DataIC50: <10nM EC50:  34nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30418(BMCL185002 Compound 3a | BMCL19451 Compound 2 | py...)
Affinity DataIC50: <10nM EC50:  12nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30530(5,6-Dihydro-1H-pyridin-2-one, 4ad)
Affinity DataIC50: <10nM EC50:  16nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30516(5,6-Dihydro-1H-pyridin-2-one, 4p)
Affinity DataIC50: <10nM EC50:  60nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30508(5,6-Dihydro-1H-pyridin-2-one, 4h)
Affinity DataIC50: <10nM EC50:  24nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30504(5,6-Dihydro-1H-pyridin-2-one, 4d)
Affinity DataIC50: <10nM EC50:  23nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30490(1,1-dioxoisothiazole analog., 34)
Affinity DataIC50: <10nM EC50:  70nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30458(benzothiazine-containing analog, 3b)
Affinity DataIC50: <10nM EC50:  2.70nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30407(5-hydroxy- 3(2H)-pyridazinone, 2 | BMCL185002 Comp...)
Affinity DataIC50: <10nM EC50:  5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30410(pyrrolo[1,2-b]pyridazin-2-one analog., 3c)
Affinity DataIC50: <10nM EC50:  8.5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30415(pyrrolo[1,2-b]pyridazin-2-one analog., 3h)
Affinity DataIC50: <10nM EC50:  5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30418(BMCL185002 Compound 3a | BMCL19451 Compound 2 | py...)
Affinity DataIC50: <10nM EC50:  12nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30407(5-hydroxy- 3(2H)-pyridazinone, 2 | BMCL185002 Comp...)
Affinity DataIC50: <10nM EC50:  5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30448(benzothiazine-containing analog, 3a | pyridazin-3-...)
Affinity DataIC50: <10nM EC50:  11nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30418(BMCL185002 Compound 3a | BMCL19451 Compound 2 | py...)
Affinity DataIC50: <10nM EC50:  12nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30450(hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 4a)
Affinity DataIC50: <10nM EC50:  190nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30452(Hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 3 | hexah...)
Affinity DataIC50: <10nM EC50:  34nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30448(benzothiazine-containing analog, 3a | pyridazin-3-...)
Affinity DataIC50: <10nM EC50:  1.10nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50081636(CHEMBL3422108)
Affinity DataIC50:  11nMAssay Description:Inhibition of HCV genotype 1b BK NS5B expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30451(hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 4b)
Affinity DataIC50:  12nM EC50:  160nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM35570(1H-benzo[de]isoquinoline-1,3(2H)-dione, 19)
Affinity DataIC50: <14nM EC50:  2.20E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30460(benzothiazine-containing analog, 3d)
Affinity DataIC50:  15nM EC50:  3.5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30456(hexahydro-1H-pyrido[1,2-b]pyridazin-2-one, 4g)
Affinity DataIC50:  16nM EC50:  300nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30495(1,1-dioxoisothiazole analog., 39)
Affinity DataIC50:  18nM EC50:  350nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30461(benzothiazine-containing analog, 3e)
Affinity DataIC50:  18nM EC50:  36nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM35563(1H-benzo[de]isoquinoline-1,3(2H)-dione, 12)
Affinity DataIC50:  19nM EC50:  3.80E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50081635(CHEMBL3422107)
Affinity DataIC50:  19nMAssay Description:Inhibition of HCV genotype 1b BK NS5B expressed in Escherichia coli BL21 (DE3) after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM35553(1H-benzo[de]isoquinoline-1,3(2H)-dione, 1)
Affinity DataIC50:  20nM EC50:  7.10E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30523(5,6-Dihydro-1H-pyridin-2-one, 4w)
Affinity DataIC50:  20nM EC50:  170nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30505(5,6-Dihydro-1H-pyridin-2-one, 4e)
Affinity DataIC50:  22nM EC50:  150nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30491(1,1-dioxoisothiazole analog., 35)
Affinity DataIC50:  23nM EC50:  90nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM35560(1H-benzo[de]isoquinoline-1,3(2H)-dione, 9)
Affinity DataIC50:  24nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30419(pyrrolo[1,2-b]pyridazin-2-one analog., 3l)
Affinity DataIC50:  25nM EC50:  22nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30411(pyrrolo[1,2-b]pyridazin-2-one analog., 3d)
Affinity DataIC50:  27nM EC50:  19nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30467(benzothiazine-containing analog, 4b)
Affinity DataIC50:  27nM EC50:  13nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30534(5,6-Dihydro-1H-pyridin-2-one, 4af)
Affinity DataIC50:  27nM EC50:  120nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30522(5,6-Dihydro-1H-pyridin-2-one, 4v)
Affinity DataIC50:  28nM EC50:  880nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM35558(1H-benzo[de]isoquinoline-1,3(2H)-dione, 7)
Affinity DataIC50:  29nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM35569(1H-benzo[de]isoquinoline-1,3(2H)-dione, 18)
Affinity DataIC50:  30nM EC50:  1.90E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM30531(5,6-Dihydro-1H-pyridin-2-one, 4ae)
Affinity DataIC50:  31nM EC50:  220nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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