Compile Data Set for Download or QSAR
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Found 1140 of ic50 for UniProtKB: P40763
LigandPNGBDBM50408828(CHEMBL5270588)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human H-PGDS expressed in Escherichia coli BL21 DE2 by enzyme immuno assay at 50 uMMore data for this Ligand-Target Pair
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LigandPNGBDBM50588525(CHEMBL5177956)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50588528(CHEMBL5209107)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50588530(CHEMBL5201151)
Affinity DataIC50:  13nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  18nMAssay Description:Inhibition of IFN-alpha induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IFN-alpha stimulation and meas...More data for this Ligand-Target Pair
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LigandPNGBDBM50588531(CHEMBL5171007)
Affinity DataIC50:  20nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  20nMAssay Description:Inhibition of IL-23 stimulated STAT3 production in human naive T cell preincubated with compound for 10 to 15 mins followed by IL-23 stimulation and ...More data for this Ligand-Target Pair
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LigandPNGBDBM50588507(CHEMBL5178622)
Affinity DataIC50:  22nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Stat3 phosphorylation in human SET2 cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
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LigandPNGBDBM50590873(CHEMBL5176684)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
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LigandPNGBDBM50588526(CHEMBL5189135)
Affinity DataIC50:  28nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50588514(CHEMBL5184385)
Affinity DataIC50:  31nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590921(CHEMBL5176948)
Affinity DataIC50:  32nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
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LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  33nMAssay Description:Inhibition of IL-6 induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IL-6 stimulation and measured after...More data for this Ligand-Target Pair
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LigandPNGBDBM50612060(CHEMBL5279856)
Affinity DataIC50:  35nMAssay Description:Inhibition of STAT3 phosphorylation a in human MOLM16 cellsMore data for this Ligand-Target Pair
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LigandPNGBDBM50588527(CHEMBL5201419)
Affinity DataIC50:  36nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590882(CHEMBL5182844)
Affinity DataIC50:  37nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50588529(CHEMBL5209399)
Affinity DataIC50:  38nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50588524(CHEMBL5205645)
Affinity DataIC50:  39nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590895(CHEMBL5185530)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  40nMAssay Description:Inhibition of IL-2 induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IL-2 stimulation and measured after...More data for this Ligand-Target Pair
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LigandPNGBDBM50588518(CHEMBL5175035)
Affinity DataIC50:  40nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590914(CHEMBL5199234)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50021656(BARICITINIB | INCB-028050 | LY-3009104 | US1011290...)
Affinity DataIC50:  44nMAssay Description:Inhibition of IL-6 stimulated STAT3 phosphorylation in human PBMC preincubated with compound for 10 to 15 mins followed by IL-6 stimulation and measu...More data for this Ligand-Target Pair
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LigandPNGBDBM50588532(CHEMBL5200170)
Affinity DataIC50:  46nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590923(CHEMBL5196490)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590919(CHEMBL5189947)
Affinity DataIC50:  58nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590911(CHEMBL5170615)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590879(CHEMBL5182625)
Affinity DataIC50:  64nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50588505(CHEMBL5206754)
Affinity DataIC50:  64nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50569071(CHEMBL4846365)
Affinity DataIC50:  67nMAssay Description:Inhibition of IL-6 induced STAT3 transcriptional activity in human HepG2 cells incubated for 1 hr followed by stimulation with IL-6 for 5.5 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50300648(4-(3-((S)-1-((cis)-2-((S)-5-amino-1-(benzylamino)-...)
Affinity DataIC50:  68nMAssay Description:Inhibition of Stat3 SH2 domain by fluorescence polarization assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50300658(4-((E)-3-((S)-1-((1R,2S,5S)-2-(2-(benzyloxy)ethylc...)
Affinity DataIC50:  69nMAssay Description:Inhibition of Stat3 SH2 domain by fluorescence polarization assayMore data for this Ligand-Target Pair
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LigandPNGBDBM50300657(4-(3-((S)-1-((cis)-2-((2R,3S)-6-amino-2-(benzyloxy...)
Affinity DataIC50:  69nMAssay Description:Inhibition of Stat3 SH2 domain by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50588501(CHEMBL5193538)
Affinity DataIC50:  72nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590920(CHEMBL5171708)
Affinity DataIC50:  76nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50588506(CHEMBL5201590)
Affinity DataIC50:  76nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50335201(5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Stat3 phosphorylation in human HEL cells after 1 hr by Western blottingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50545650(Delgocitinib | JTE-052 | JTE-052A | LEO 124249 | L...)
Affinity DataIC50:  84nMAssay Description:Inhibition of IL-23 induced STAT3 phosphorylation in human PBMC preincubated with compound for 30 mins followed by IL-23 stimulation and measured aft...More data for this Ligand-Target Pair
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LigandPNGBDBM50590889(CHEMBL5177332)
Affinity DataIC50:  88nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590909(CHEMBL5189774)
Affinity DataIC50:  93nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590916(CHEMBL5183263)
Affinity DataIC50:  94nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50300656(4-(3-((S)-1-((cis)-2-((S)-5-amino-1-(benzyloxy)-5-...)
Affinity DataIC50:  94nMAssay Description:Inhibition of Stat3 SH2 domain by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM420304(LLL-12)
Affinity DataIC50:  98nMAssay Description:Inhibition of IL-6 induced STAT3 transcriptional activity in human HepG2 cells incubated for 1 hr followed by stimulation with IL-6 for 5.5 hrs by lu...More data for this Ligand-Target Pair
Ligand InfoPurchase
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LigandPNGBDBM50588512(CHEMBL5201252)
Affinity DataIC50:  101nMAssay Description:Inhibition of STAT3 in human HEK293T cells assessed as inhibition of IL-6 stimulated STAT3 phosphorylation by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50213228(2-(4-((S)-3-((S)-1-((S)-2-(((S)-5-amino-1-((2S,3R)...)
Affinity DataIC50:  108nMAssay Description:Inhibition of STAT3 dimer DNA binding activity by ELISA after 30 minsMore data for this Ligand-Target Pair
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LigandPNGBDBM50590894(CHEMBL5199713)
Affinity DataIC50:  109nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50300627(4-(3-((S)-1-((S)-2-((R)-5-amino-5-oxopentan-2-ylca...)
Affinity DataIC50:  110nMAssay Description:Inhibition of Stat3 SH2 domain by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50590912(CHEMBL5189465)
Affinity DataIC50:  113nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM50590918(CHEMBL5200334)
Affinity DataIC50:  113nMAssay Description:Inhibition of human recombinant STAT3 (127 to 722 residues) transcriptional activity expressed in HEK293T cells in presence of IL-6 by Dual-luciferas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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