Compile Data Set for Download or QSAR
maximum 50k data
Found 35 of ic50 for UniProtKB: P0C6X6
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525229(N-[(1S)-1-(1-bicyclo[1.1.1]pentanylmethyl)-2-[2-[(...)
Affinity DataIC50:  11nMAssay Description: For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525230(WO2022043374, Example 72)
Affinity DataIC50:  13nMAssay Description: For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525228(N-[(1S)-2-[2-[(2R)-2-chloro-2-fluoro-acetyl]-2-[[(...)
Affinity DataIC50:  15nMAssay Description: For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525176(N-[(1S)-1-[[(3-amino-3-oxo-propyl)-(2-chloroacetyl...)
Affinity DataIC50:  17nMAssay Description: For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525251(N-[(1S)-2-[2-[(2R)-2-chloro-2-fluoro-acetyl]-2-[[(...)
Affinity DataIC50:  17nMAssay Description: For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525203(N-[(1S)-1-[[(2-Chloroacetyl)-[(2-oxo-pyrrolidin-3-...)
Affinity DataIC50:  19nMAssay Description: For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525250(N-[(1S)-1-(1-bicyclo[1.1.1]pentanylmethyl)-2-[2-[(...)
Affinity DataIC50:  21nMAssay Description: For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525252(N-[(1S)-1-[[[(2R)-2-chloro-2-fluoro-acetyl]-[[(3S)...)
Affinity DataIC50:  23nMAssay Description: For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM448319(GC-376 | GC376)
Affinity DataIC50:  28nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM525253(WO2022043374, Example 73)
Affinity DataIC50:  41nMAssay Description: For the HCoV-OC433CLpro assay, 2 μL of 0.02 μM recombinant HCoV-OC433CL protease were mixed with serial dilutions of each comp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50:  110nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM484195(UAWJ9-36-3)
Affinity DataIC50:  110nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420980(US9975885, Compound 37)
Affinity DataIC50:  2.20E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420974(US9975885, Compound 30)
Affinity DataIC50:  2.70E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420977(US9975885, Compound 32)
Affinity DataIC50:  2.80E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420960(US9975885, Compound 19)
Affinity DataIC50:  3.90E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420981(US9975885, Compound 64)
Affinity DataIC50:  4.50E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420975(US9975885, Compound 31)
Affinity DataIC50:  5.80E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420337(US9975885, Compound 1P)
Affinity DataIC50:  6.90E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420996(US9975885, Compound 77)
Affinity DataIC50:  7.00E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420978(US9975885, Compound 33)
Affinity DataIC50:  7.30E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420993(US9975885, Compound 47)
Affinity DataIC50:  7.70E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand InfoPDB
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420979(US9975885, Compound 34)
Affinity DataIC50:  8.90E+3nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420349(US9975885, Compound 6)
Affinity DataIC50:  1.00E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420973(US9975885, Compound 29)
Affinity DataIC50:  1.11E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420990(US9975885, Compound 43)
Affinity DataIC50:  1.24E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420987(US9975885, Compound 40)
Affinity DataIC50:  1.37E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420983(US9975885, Compound 3P | med.21724, Compound 125)
Affinity DataIC50:  1.37E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420991(US9975885, Compound 44)
Affinity DataIC50:  1.56E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420972(US9975885, Compound 27)
Affinity DataIC50:  1.63E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420985(US9975885, Compound 38)
Affinity DataIC50:  2.44E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420961(US9975885, Compound 2P | acs.jmedchem.1c00409_ST.4...)
Affinity DataIC50:  2.44E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420992(US9975885, Compound 46)
Affinity DataIC50:  2.45E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420994(US9975885, Compound 48)
Affinity DataIC50:  4.65E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(HCoV-OC43)
F. Hoffmann-La Roche

WIPO
LigandPNGBDBM420989(US9975885, Compound 42)
Affinity DataIC50:  6.31E+4nMAssay Description:The inhibitor library was first screened for inhibition of each 3CLpro at a concentration of 100 μM in duplicate assays containing the following...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent