TargetDimer of Prostaglandin G/H synthase 2(Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 130nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Binding affinity to human COX2More data for this Ligand-Target Pair
TargetDimer of Prostaglandin G/H synthase 2 [Y385F](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 1.60E+3nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [Y385F](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 370nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [R120A,Y385F](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 620nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetDimer of Prostaglandin G/H synthase 2 [R120Q](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 220nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetDimer of Prostaglandin G/H synthase 2 [R120A](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 750nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetDimer of Prostaglandin G/H synthase 2 [S530A](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 190nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2 [S530A](Homo sapiens (Human))
University of Michigan Medical School
University of Michigan Medical School
Affinity DataKd: 240nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
Affinity DataKd: 8.07E+3nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataKd: 230nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 51.3nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 203nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 51.1nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 40.8nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 14.0nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 56.4nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 3.30nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 3.30nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 1.02E+3nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 789nMAssay Description:Inhibitory activity of the synthesized compounds on COX-1 and COX-2 enzymes were evaluated at 40 μm using the COX Inhibitor Screening Assay Kit ...More data for this Ligand-Target Pair
Affinity DataKd: 0.190nMAssay Description:Binding affinity to COX2 by surface plasmon resonance spectroscopyMore data for this Ligand-Target Pair
Affinity DataKd: 652nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 448nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 227nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 92nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 50nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 48nMAssay Description:Binding affinity to COX2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKd: 160nMpH: 8.0Assay Description:POX reactions were conducted in 2 ml of filtered and degassed 50 mM Tris-HCl, pH 8.0, containing 50 mM NaCl, 0.1 mM H2O2, 4.5 mM guaiacol, and the in...More data for this Ligand-Target Pair
