Compile Data Set for Download or QSAR
maximum 50k data
Found 200 of ic50 for UniProtKB: P18266
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM17149(2-imino-thiazolidin-4-one analog, 11 | 4-(5-{[(5Z)...)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7262(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity in phenoxybenzamine-treated rat by Pressor assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7262(14-nitro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  4nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM3175(3-[1-[3-(Amidinothio)propyl]-3-indolyl]-4-(1-methy...)
Affinity DataIC50:  6.80nMAssay Description:Inhibition of Wistar rat GSK-3beta using RRAAEELDSRAGS(P)PQL as substrate after 15 mins in presence of [gamma-32P]-ATP by scintillation counting meth...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7492(3-[(2Z,3E)-3-(hydroxyimino)-2,3-dihydro-1H-indol-2...)
Affinity DataIC50:  9nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM50259155((Z)-Hymenialdisine | Hymenialdisine)
Affinity DataIC50:  10nMAssay Description:Antagonist activity in phenoxybenzamine-treated rat by Pressor assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7263(9-cyanopaullone | 9-oxo-8,18-diazatetracyclo[9.7.0...)
Affinity DataIC50:  10nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7491((4Z)-4-(2-amino-5-oxo-3,5-dihydro-4H-imidazol-4-yl...)
Affinity DataIC50:  10nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7264(2,3-dimethoxy-9-nitropaullone | 4,5-dimethoxy-14-n...)
Affinity DataIC50:  13nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM17150(2-chloro-4-(5-{[(5Z)-2-imino-4-oxo-1,3-thiazolidin...)
Affinity DataIC50:  14nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  15nMAssay Description:Antagonist activity in rat uterus by uterotonic assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7322(14-bromo-5-hydroxy-8,18-diazatetracyclo[9.7.0.0^{2...)
Affinity DataIC50:  18nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  18nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7265(4,5-dimethoxy-9-oxo-8,18-diazatetracyclo[9.7.0.0^{...)
Affinity DataIC50:  18nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)
Affinity DataIC50:  18nMAssay Description:Inhibition of rat GSK3beta expressed in Sf9 cells incubated for 30 mins using GS-1 peptide substrate and [gamma-32P]ATP by scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM50166289(CHEBI:43645 | CHEMBL216543)
Affinity DataIC50:  22nMAssay Description:Antagonist activity in phenoxybenzamine-treated rat by Pressor assayMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7330(2-Methoxy-9-nitro-7,12-dihydro-indolo[3,2-d][1]ben...)
Affinity DataIC50:  22nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7266(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  23nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7266(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  23nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7266(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity in rat uterus by uterotonic assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7267(14-chloro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12...)
Affinity DataIC50:  24nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7335(5-(4-aminobutoxy)-14-bromo-8,18-diazatetracyclo[9....)
Affinity DataIC50:  30nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7268(14-(trifluoromethyl)-8,18-diazatetracyclo[9.7.0.0^...)
Affinity DataIC50:  30nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7269(3-(6-oxo-9-trifluoromethyl-5,6,7,12-tetrahydro-ind...)
Affinity DataIC50:  33nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7340(13-nitro-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6}...)
Affinity DataIC50:  35nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM50408385(CHEMBL5280328)
Affinity DataIC50:  40nMAssay Description:Antagonist activity in phenoxybenzamine-treated rat by Pressor assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)
Affinity DataIC50:  66nMAssay Description:Inhibition of recombinant rat N-terminal GST-tagged GSK3beta expressed in Escherichia coli assessed as reduction in tau phosphorylation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7329(3-Methoxy-9-nitro-7,12-dihydro-indolo[3,2-d][1]ben...)
Affinity DataIC50:  70nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7271(9-bromo-12-methyloxycarbonylmethylpaullone | CHEMB...)
Affinity DataIC50:  75nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7270(2,3-dimethoxy-9-trifluoromethylpaullone | 4,5-dime...)
Affinity DataIC50:  75nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7272(14-fluoro-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12...)
Affinity DataIC50:  80nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM17144(2-imino-thiazolidin-4-one analog, 6 | 4-(5-{[(5Z)-...)
Affinity DataIC50:  80nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7325(2-(2-oxopropyl)-9-(trifluoromethyl)-7,12-dihydroin...)
Affinity DataIC50:  90nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7273(14-bromo-4,5-dimethoxy-8,18-diazatetracyclo[9.7.0....)
Affinity DataIC50:  100nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7336(13-bromo-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6}...)
Affinity DataIC50:  120nMpH: 7.5 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7336(13-bromo-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6}...)
Affinity DataIC50:  120nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7336(13-bromo-3-thia-7,17-diazatetracyclo[8.7.0.0^{2,6}...)
Affinity DataIC50:  120nMAssay Description:Inhibition of rat GSK3beta expressed in Sf9 cells incubated for 30 mins using GS-1 peptide substrate and [gamma-32P]ATP by scintillation counting met...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7274(14-bromo-4,5-dihydroxy-8,18-diazatetracyclo[9.7.0....)
Affinity DataIC50:  120nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7328(3-Methoxy-6-oxo-5,6,7,12-tetrahydro-indolo[3,2-d][...)
Affinity DataIC50:  130nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7275(14-methyl-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12...)
Affinity DataIC50:  130nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7276(10-bromopaullone | 15-bromo-8,18-diazatetracyclo[9...)
Affinity DataIC50:  140nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM11448(4-{[5-(cyclohexyloxy)-[1,2,4]triazolo[1,5-a]pyrimi...)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7278(11-chloropaullone | 16-chloro-8,18-diazatetracyclo...)
Affinity DataIC50:  200nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7279(2-(3-hydroxy-1-propinyl)-9-trifluoromethylpaullone...)
Affinity DataIC50:  200nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7280(2-Bromo-9-Nitropaullone | 4-bromo-14-nitro-8,18-di...)
Affinity DataIC50:  200nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7277(2-Bromopaullone | 4-bromo-8,18-diazatetracyclo[9.7...)
Affinity DataIC50:  200nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7320(3-Methoxy-9-trifluormethyl-7,12-dihydro-indolo[3,2...)
Affinity DataIC50:  240nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM7281(2-iodopaullone | 4-iodo-8,18-diazatetracyclo[9.7.0...)
Affinity DataIC50:  250nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM17141(2-imino-thiazolidin-4-one analog, 1 | 4-(5-{[(5Z)-...)
Affinity DataIC50:  250nMpH: 7.5 T: 2°CAssay Description:In vitro kinase assay using purified GSK-3 beta was incubated at room temperature with substrate, and test compounds in the presence of 10 uM ATP/ [g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Rattus norvegicus (rat))
Vernalis (R&D)

LigandPNGBDBM5655(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Affinity DataIC50:  280nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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