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Found 3193 with your filter
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50:  0.0180nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50045179((R)-4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-pyrrolidi...)
Affinity DataIC50:  0.0200nMAssay Description:Agonistic activity at kappa opioid receptor of rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50045192(4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-(3,6-dihydro-...)
Affinity DataIC50:  0.0400nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50:  0.0410nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50027433(CHEMBL603370 | GR-89696)
Affinity DataIC50:  0.0410nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50000293(2-(3,4-Dichloro-phenyl)-1-(7-pyrrolidin-1-ylmethyl...)
Affinity DataIC50:  0.100nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50582290(CHEMBL5082614 | US20230286958, Example 198)
Affinity DataIC50:  0.100nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50000293(2-(3,4-Dichloro-phenyl)-1-(7-pyrrolidin-1-ylmethyl...)
Affinity DataIC50:  0.100nMAssay Description:In vitro kappa-opioid receptor agonist activity in isolated rabbit vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50001107(2-(3,4-Dichloro-phenyl)-1-(5-hydroxy-1-pyrrolidin-...)
Affinity DataIC50:  0.110nMAssay Description:In vitro kappa-opioid receptor agonist activity in isolated rabbit vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50582290(CHEMBL5082614 | US20230286958, Example 198)
Affinity DataIC50:  0.200nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50582291(CHEMBL5078294 | US20230286958, Example 200)
Affinity DataIC50:  0.200nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50582287(CHEMBL5079850 | US20230286958, Example 41)
Affinity DataIC50:  0.200nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50582288(CHEMBL5089406 | US20230286958, Example 136)
Affinity DataIC50:  0.200nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50582291(CHEMBL5078294 | US20230286958, Example 200)
Affinity DataIC50:  0.200nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50280147(1-[4-Acetyl-2-((S)-3-hydroxy-pyrrolidin-1-ylmethyl...)
Affinity DataIC50:  0.220nMAssay Description:Agonistic activity at kappa opioid receptor of rabbit vas deferensMore data for this Ligand-Target Pair
In DepthDetails Article
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50045186(4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-(3-methoxycar...)
Affinity DataIC50:  0.280nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617989(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50:  0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617991(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-(...)
Affinity DataIC50:  0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617993(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50:  0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617832(US20230286958, Example 44)
Affinity DataIC50:  0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM618006(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N(1...)
Affinity DataIC50:  0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617940(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50:  0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50582289(CHEMBL5076760 | US20230286958, Example 155)
Affinity DataIC50:  0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617993(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50:  0.300nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50045196(4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-(3-hydroxy-py...)
Affinity DataIC50:  0.340nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50045193(4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-(3-oxo-pyrrol...)
Affinity DataIC50:  0.340nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM618017(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-(...)
Affinity DataIC50:  0.370nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50039101(2-(3,4-Dichloro-phenyl)-1-[4-(3-hydroxy-pyrrolidin...)
Affinity DataIC50:  0.390nMAssay Description:In vitro kappa-opioid receptor agonist activity in isolated rabbit vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617802(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-m...)
Affinity DataIC50:  0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617827(US20230286958, Example 39)
Affinity DataIC50:  0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM618014(US20230286958, Example 226)
Affinity DataIC50:  0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM618022(6-(3-Chloro-6-cyano-2-fluorophenyl)-3-methyl-N-(1-...)
Affinity DataIC50:  0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617898(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50:  0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617970(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-(...)
Affinity DataIC50:  0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617989(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50:  0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617998(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-(...)
Affinity DataIC50:  0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617955(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50:  0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM618028(6-(3-Chloro-6-(difluoromethoxy)-2-fluorophenyl)-3-...)
Affinity DataIC50:  0.400nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50045189(1-{4-[2-(3,4-Dichloro-phenyl)-acetyl]-3-pyrrolidin...)
Affinity DataIC50:  0.420nMAssay Description:In vitro agonist activity at kappa opioid receptor in rabbit vas deferens.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Sterling Research Group

Curated by ChEMBL
LigandPNGBDBM50229939(CHEMBL423481)
Affinity DataIC50:  0.460nMAssay Description:Concentration required to displace 50% of 0.5 nM [3H](aminoalkyl)indole binding to cannabinoid receptor in rat cerebellum membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Glaxo Group Research

Curated by ChEMBL
LigandPNGBDBM50039104((SS)-2-(3,4-Dichloro-phenyl)-1-[4-(3-hydroxy-pyrro...)
Affinity DataIC50:  0.470nMAssay Description:In vitro kappa-opioid receptor agonist activity in isolated rabbit vas deferens assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617800(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N- ...)
Affinity DataIC50:  0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555385(CHEMBL4753307)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM50555401(CHEMBL4742233)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Sareum

Curated by ChEMBL
LigandPNGBDBM328998(1137478-52-4 | US11787792, Compound Y-158 | US9663...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of CHK1 (unknown origin) using 5-FAM-KKKVSRSGLYRSPSMPENLNRPR-COOH peptide as substrate incubated for 1 hr in presence of ATP by caliper mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617867(4-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-1-m...)
Affinity DataIC50:  0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617907(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-m...)
Affinity DataIC50:  0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617914(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-3-(...)
Affinity DataIC50:  0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617915(6-(3-Chloro-6-(difluoromethyl)-2-fluorophenyl)-N-(...)
Affinity DataIC50:  0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM617919(6-(3-Chloro-6-(difluoromethoxy)-2-fluorophenyl)-3-...)
Affinity DataIC50:  0.5nMAssay Description:Kallikrein determinations were made in 50 mM HEPES buffer at pH 7.4 containing 150 mM NaCl, 5 mM CaC12, and 0.1% PEG 8000 (polyethylene glycol; Fishe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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