Compile Data Set for Download or QSAR
maximum 50k data
Found 47 Enz. Inhib. hit(s) with all data for entry = 50032604
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331795(1,1,1-trifluoro-2-(1-((2-(2-hydroxypropan-2-yl)-3-...)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331796(1,1,1-trifluoro-2-(1-((2-(1-hydroxyethyl)-3-phenyl...)
Affinity DataKi:  3.80E+3nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331797(1-(3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan-...)
Affinity DataKi:  4.40E+3nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331806(CHEMBL1290649 | methyl 3-phenyl-6-((4-(1,1,1-trifl...)
Affinity DataKi:  6.30E+3nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331804((R)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataKi:  1.10E+4nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331803((S)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataKi:  1.30E+4nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331794(1,1,1-trifluoro-2-(1-((2-(hydroxymethyl)-3-phenylb...)
Affinity DataKi:  1.30E+4nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331802((S)-3-(3-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataKi:  1.40E+4nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331801((S)-3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan...)
Affinity DataKi:  1.60E+4nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331800(3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan-2-y...)
Affinity DataKi:  1.70E+4nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331799(CHEMBL1289329 | N-methyl-3-phenyl-6-((4-(1,1,1-tri...)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331798(CHEMBL1289328 | N,N-dimethyl-3-phenyl-6-((4-(1,1,1...)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331805((S)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331793(3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan-2-y...)
Affinity DataKi: >2.00E+4nMAssay Description:Displacement of labeled MK-499 from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331806(CHEMBL1290649 | methyl 3-phenyl-6-((4-(1,1,1-trifl...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331797(1-(3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan-...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331794(1,1,1-trifluoro-2-(1-((2-(hydroxymethyl)-3-phenylb...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331803((S)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50:  21nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331801((S)-3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331802((S)-3-(3-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50:  31nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331801((S)-3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan...)
Affinity DataIC50:  32nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331802((S)-3-(3-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331807(1,1,1-trifluoro-2-(1-((3-phenylbenzo[b]thiophen-6-...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331800(3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan-2-y...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331803((S)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331794(1,1,1-trifluoro-2-(1-((2-(hydroxymethyl)-3-phenylb...)
Affinity DataIC50:  64nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331800(3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan-2-y...)
Affinity DataIC50:  70nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331797(1-(3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan-...)
Affinity DataIC50:  84nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331796(1,1,1-trifluoro-2-(1-((2-(1-hydroxyethyl)-3-phenyl...)
Affinity DataIC50:  88nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331804((R)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50:  154nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331796(1,1,1-trifluoro-2-(1-((2-(1-hydroxyethyl)-3-phenyl...)
Affinity DataIC50:  161nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331795(1,1,1-trifluoro-2-(1-((2-(2-hydroxypropan-2-yl)-3-...)
Affinity DataIC50:  198nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331799(CHEMBL1289329 | N-methyl-3-phenyl-6-((4-(1,1,1-tri...)
Affinity DataIC50:  223nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331806(CHEMBL1290649 | methyl 3-phenyl-6-((4-(1,1,1-trifl...)
Affinity DataIC50:  260nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331799(CHEMBL1289329 | N-methyl-3-phenyl-6-((4-(1,1,1-tri...)
Affinity DataIC50:  263nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331795(1,1,1-trifluoro-2-(1-((2-(2-hydroxypropan-2-yl)-3-...)
Affinity DataIC50:  392nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331807(1,1,1-trifluoro-2-(1-((3-phenylbenzo[b]thiophen-6-...)
Affinity DataIC50:  598nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331804((R)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331798(CHEMBL1289328 | N,N-dimethyl-3-phenyl-6-((4-(1,1,1...)
Affinity DataIC50:  1.84E+3nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331798(CHEMBL1289328 | N,N-dimethyl-3-phenyl-6-((4-(1,1,1...)
Affinity DataIC50:  1.89E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331805((S)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331793(3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan-2-y...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human recombinant 5-lipoxygenase assessed as arachidonic acid oxidationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331803((S)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of 5-lipoxygenase activating proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331803((S)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of 15-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331803((S)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331805((S)-3-(4-fluorophenyl)-6-((4-(1,1,1-trifluoro-2-hy...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50331793(3-phenyl-6-((4-(1,1,1-trifluoro-2-hydroxybutan-2-y...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of 5-lipoxygenase in human whole blood assessed as inhibition of LTB4 productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed