Compile Data Set for Download or QSAR
maximum 50k data
Found 16 Enz. Inhib. hit(s) with all data for entry = 50038074
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50163592((3,4-Dihydro-2H-1-oxa-9-aza-anthracen-6-yl)-(4-met...)
Affinity DataIC50:  1.21nMAssay Description:Antagonist activity at human mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50177053(9-Dimethylamino-3-(4-ethyl-phenyl)-3H-pyrido[3',2'...)
Affinity DataIC50:  3nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50212328(4-(1-(2-fluoropyridin-3-yl)-5-methyl-1H-1,2,3-tria...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50212324(6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-alph...)
Affinity DataIC50:  16nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50212322(4-methoxyphenyl-6-methoxyquinazolin-4-yl | CHEMBL2...)
Affinity DataIC50:  96nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50212323((3aS,6aS)-5-methylene-6a-(naphthalen-2-ylmethyl)-h...)
Affinity DataIC50:  160nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50212327(3-(amino(carboxy)(9H-thioxanthen-9-yl)methyl)cyclo...)
Affinity DataIC50:  1.00E+3nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50212325((S)-(ALPHA)-METHYL-4-CARBOXYPHENYLGLYCINE | (S)-4-...)
Affinity DataIC50:  4.30E+3nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50212325((S)-(ALPHA)-METHYL-4-CARBOXYPHENYLGLYCINE | (S)-4-...)
Affinity DataIC50:  4.30E+3nMAssay Description:Antagonist activity at mGlu2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM86213(CAS_5126051 | CHEMBL327783 | CPCCOEt | NSC_5126051)
Affinity DataIC50:  6.60E+3nMAssay Description:Antagonist activity at human mGlu1b receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053588((S)-4-(amino(carboxy)methyl)benzoic acid | (S)-4-c...)
Affinity DataIC50:  1.00E+4nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50052256((S)-3-(amino(carboxy)methyl)bicyclo[1.1.1]pentane-...)
Affinity DataIC50:  2.50E+4nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053586((S)-3-Carboxy-4-hydroxyphenylglycine | (S)-5-(amin...)
Affinity DataIC50:  4.00E+4nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053585((S)-4-(amino(carboxy)methyl)-2-hydroxybenzoic acid...)
Affinity DataIC50:  4.00E+4nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50400856(CHEMBL2021372)
Affinity DataIC50:  2.30E+5nMAssay Description:Antagonist activity at mGlu1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50053585((S)-4-(amino(carboxy)methyl)-2-hydroxybenzoic acid...)
Affinity DataEC50:  4.80E+4nMAssay Description:Agonist activity at mGlu2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed